The main scientific directions of LEFH are:

• Optimization of commercial catalytic processes for the production of environmentally-friendly conventional fuels in integrated refineries (fluid catalytic cracking, hydroprocessing, hydrocracking, isomerization, reforming;
• Development of novel processes for the production of 2nd and 3rd generation biofuels and the upgrading of low-quality biofuels (in-situ and ex-situ catalytic pyrolysis of biomass, upgrading of heavy bio-based fuels, co-processing of low-quality biofuels with conventional oils in existing refinery processes);
• Exploitation of waste streams (CO₂, plastics, organic wastes, end-of-life tires etc.) for the production of renewable fuels and chemicals via catalytic technologies in the context of circular economy
• Development of catalytic processes for the production of biochemicals from various hydrolysates (fermentation broths, hydrolysates from biomass pretreatment technologies etc)
• Development of innovative organosolve-based biomass pretreatment technologies
• Process intensification for the efficient conversion of CO₂ to high-added-value products
• Catalytic processes for the reduction of SΟx, ΝΟx and CO emissions from the flue gases of FCC unit regenerators.