The Laboratory of Polymer Reaction Engineering (LPRE) was established in 1985 within the Department of Chemical Engineering of Aristotle University of Thessaloniki. The Laboratory is also associated with the Chemical Process Engineering Research Institute (CPERI) a non-profit, rapidly growing research organization.
The LPRE is supported to a large extent through research funds from the Greek Secretariat of Research and Technology, the European Union, the Aristotle University of Thessaloniki, and major European Polymer Manufacturing Industries.
The Laboratory’s research activities fall into the following general areas:
- Design, optimization and computer control of polymerization reactors (CAD/CAM)
- Mathematical modeling and experimental investigation of polymer production processes
- Hardware and software sensors for on-line polymer quality monitoring
- Molecular, physical and morphological characterization of polymers
- Theoretical and experimental investigation of macro- and microencapsulation techniques
- Synthesis of water-soluble polymers: structure-function relationships
- Production of porous and non-porous polymer microparticles
- Synthesis and transport properties of polymer membranes and films
- Production of novel high-added value functional biopolymers from renewable sources
The Laboratory is equipped with experimental facilities (i.e., several high-pressure bench scale reactors) for the production of polymers and analytical equipment (i.e., GPC, DSC/TGA, GC, FTIR, Laser Diffraction Particle Size Analyser, X-Rays, Mercury Porosimeter, UV spectrometer, etc.) for their characterization. It has an up-to-date computer network which includes two Silicon Graphics workstations, as well as over sixty personal computers.
Presently the Laboratory employs ten doctoral research associates, twelve Ph.D. candidates, three research associates and two technicians. Its present annual budget is over Euro € 800,000.
The main objective of the Laboratory of Polymer Reaction Engineering (LPRE) is to carry out innovative, collaborative research work, the results of which can be applied to the long-term needs of the Greek and European Polymer Industries with a special emphasis given in the area of polymer reaction design, optimization and control.
Areas of Research & Development
The Laboratory’s research activities fall into the following general areas:
- Catalyzed gas-phase olefin polymerization in fluidized bed reactors
- Polymerization in supercritical fluids
- Suspension and emulsion polymerization: experimental and theoretical studies
- Software and hardware sensor developments for the on-line monitoring of polymer quality
- Modeling, monitoring and diagnosis of polymer reactors by PLS and ANN methods
- Molecular and morphological characterization of polymers
- Chemical modification of polymers under processing conditions
- Production of porous and non-porous polymer microparticles
- Synthetic polymer hydrogels: Structure-function relationships
- Synthesis and transport properties of polymer membranes and films
Polymers can be synthesized from monomers by a multitude of reaction mechanisms, including addition (e.g., free-radical, ionic, group transfer and Ziegler-Natta polymerizations) and step-growth (e.g., polycondensation) reactions. The macromolecular architecture (e.g., molar mass, molecular weight distribution (MWD), copolymer composition distribution (CCD), chain sequence length distribution (CSLD), branching distribution (BD), stereoregularity, etc.) depends not only on the chemical nature of the monomers, the type of polymerization mechanism and the physical state of the reacting system (e.g., polymerization process) but also on the type of reactor configuration.
A major objective of polymerization reaction engineering is to understand how the reaction mechanism, the physical transport phenomena (e.g., mass and heat transfer, mixing), reactor type and reactor operating conditions affect the “polymer quality” of the final product. The term “polymer quality” includes all the molecular structure properties (e.g., MWD, CCD, BD, stereoregularity, etc.) and the macroscopic morphological properties of the polymer product (e.g., particle size distribution, porosity, bulk density, etc.). The various chemical and physical phenomena occurring in a polymer reactor can be classified into the following three levels of modeling:
- Microscale chemical kinetic modeling
- Mesoscale physical /transport modeling
- Macroscale dynamic reactor modeling
Product quality is a much more complex issue in polymerization than in more conventional short chain reactions. Traditional polymerization control is carried out by sampling, off-line characterization of polymer quality in a laboratory and manual recording of the results. This practice persists today since most polymer properties are difficult to measure even off-line. Recently, advances have been made in the development of on-line measurements, but as yet, the use of new sensors has largely been confined to the monitoring of laboratory or pilot-plant reactors. New developments in fiber-optic linked devices (e.g., Raman, NIR and UV) have largely increase the scope for use of new robust sensing techniques for the monitoring of polymer quality.
A major problem in attempting to infer polymer quality, from signals generated by a range of potentially useful sensors and analyzers, is the complexity of the data produced. Multivariate statistical data analysis methods and in some cases partial least squares (PLS) techniques are considered state-of-the-art. The development of algorithms capable of accurately and reliably characterizing polymer quality associated data, that can be integrated into the sensor/analyzer system itself is an important requirement.
Time optimal open-loop control can provide temperature, monomer and initiator trajectories that can result in the production of polymers with desired properties. Unfortunately, these optimal trajectories are only valid when the dynamic model provides perfect prediction of the actual process dynamics, no disturbances enter the process and the assumed initial operating conditions are correct. This implies that the operation of a polymer reactor based on these off-line calculated trajectories will likely be suboptimal and will suffer from poor product reproducibility. Thus, model-based predictive controllers are required to ensure the realization of the polymer property specifications in the presence of initialization errors, model/plant mismatch and disturbances. These controllers must be able to perform well over a range of operating conditions in the face of strong process nonlinearities
In order to verify the theoretical results of our work and demonstrate experimentally the substantial benefits that can be gained from the application of real-time computer control to industrial polymerization reactors, lab-scale computer-controlled batch reactor systems are employed. A gas chromatograph, a viscometer, a digital densitometer and an IR spectrophotometer operate on-line with the computer-aided reactor system to monitor the concentration of monomer(s), the average molecular weight and other important process variables during the polymerization.
Although computer simulation and control have been applied to the chemical and petrochemical processes, the routine, widespread application of computer simulation, computer-aided design (CAD), computer aided process monitoring (CAPM), computer aided process optimization and control (CAPOC) methods for the polymerization processes is still very limited. However, as the polymer industry becomes more global and competitive pressures are intensifying, leading polymer manufacturers are actively engaged with the development of necessary CAD software tools for computer integrated polymer manufacturing (CIPM).
Present efforts of LPRE aim at the development of powerful, flexible, adaptive design and predictive simulation tools that can follow and predict the molecular and morphological properties of polymers produced in different reactor configurations, in an accurate, prompt and comprehensive way.
The application of controlled release devices are wide and varied. The idea behind the use of a programmed release system is that by mixing or surrounding the active ingredient with a suitable confinement material, the rate of release of the active ingredient can be controlled. Controlled release devices can either be reservoirs in which the active ingredient is surrounded by a suitable confinement material, or they can consist of matrices where the active ingredient is commonly dispersed in a polymeric material. The confinement material in both systems serves as a barrier to the active agent which is released either by diffusion through the pores of the confinement material or due to the degradation of the material. The designers of controlled release formulations or delivery systems must have an unusually high degree of understanding of a variety of design parameters and system variables in order to develop the desired degree of control.
Problems related to the development of novel confinement methods and materials are investigated. In particular, the present program is focused on the identification of all important physical and chemical factors which affect the release kinetics of selected active ingredients from reservoir and matrix confinement devices. Comprehensive mathematical models are developed to relate the molecular and morphological characteristics of the novel confinement materials to the release behaviour of active compounds.
Principal Researcher, Chemical Engineer, PhD
(+30) 2310 498168
Principal Researcher, Chemical Engineer, PhD
(+30) 2310 498162
Associate Researcher, Chemical Engineer, PhD
(+30) 2310 498165
(+30) 2310 498161
(+30) 2310 498178
(+30) 2310 498164
Chemical Engineer, MSc
(+30) 2310 498178
(+30) 2310 498172
Chemical Engineer, MSc
(+30) 2310 498178
(+30) 2310 498172
Collaborating Researchers / PhD
Chemical Engineer, PhD
(+30) 2310 498170
Chemical Engineer, PhD
(+30) 2310 498166
Chemical Engineer, PhD
(+30) 2310 498166
Chemical Engineer, PhD
(+30) 2310 498172
Administrative And Technical Staff
(+30) 2310 498179
(+30) 2310 498171
Excellent experimental facilities exist for the synthesis, molecular, morphological characterization and testing of polymers. The following equipment is available in the LPRE:
Fourier transform infrared spectrophotometer (FTIR, Perkin Elmer 2000)
Luminescence spectrophotometer (LS, Perkin Elmer LS 45)
Thermogravimetric analyzer (TGA, Perkin Elmer TGA-7)
Dynamic light scattering (Malvern Zetasizer nanoZS90- Malvern Autosizer Lo-C)
High temperature gel permeation chromatography with multiple detectors (PL-GPC210, PolymerLabs)
GC-head space chromatograph (Hewlett Packard 6890- Hewlett Packard 7694)
Scanning probe microscope (Digital Instruments, Nanoscope IIIa)
Stereomicroscope (NIKON, Model SMZ-2T)
Apparatus for measurement of polymer rheological properties
Apparatus for interfacial tension measurements (Kross, Typ K10T)
Four fully automated, high-pressure stirred autoclaves for polymer production
High pressure reactor (Parr 5100)
Spray dryer (Mini Spray Dryer, Bochi B-191)
Fluidized bed particle coating device (UniGlatt)
Extrusion device for the synthesis of liposomes (LiposoFast-Pneumatic, avestin Inc.)
Laminar flow (Thermo Electron Hera Safe KS12- Telstar Bio II A/P)
Multi stage liquid impinger (MSLI, Copley)
CO2 incubator (Heraeus, HeraCell 150)
Ultra centrifuge (Sorvall, Discovery 100SE)
Deep freezer for cell cryo-preservation
Steam Sterilizer (Raypa)
Rotary evaporator (Heidolph Laborata 4002- Heidolph Laborata 4001)
Water distilator and deionizer (GFL 2002- Elga Purelab Option S)
Uv-Vis Spectrophotometer (UV-Vis, Perkin Elmer Lambda 35, Hitachi U-1800)
Differential scanning calorimeter (DSC, Perkin Elmer DSC-7, TA Q100)
Dynamic mechanical analyzer (DMA, Perkin Elmer TAC 7/DX)
Laser diffraction particle size analyser (Malvern Mastesizer 2000- Malvern 2605c)
Gel Permeation chromatography (Varian Series)
High performance liquid chromatography (HPLC, Agilent Technologies 1200 series)
Optical Microscope- Image analysis system (Leika Optical Micro DM400B- Leitz Mettalux 3 Leika IM)
Apparatus for intrinsic viscosity measurements
Rheometer (Rheometric Scientific, SR-5000)
High-precision apparatus for density measurements
Low temperature UV-polymerization cabinet (Velp scientifica, FOC 225E)
Bioreactor for fermentation (Brunswick Scientific BioFlo 410- Brunswick Scientific BioFlo 110)
Twin-screw BRABENDER extruder (DSE φ25) and mixer (PL 2100-6)
Tangential flow filtration device (Misch)
Freeze dryer (Thermo Electon Corp. MicroModulyo)
Shaker incubator (GFL 3033)
Transepithelial electrical resistance (TEER) voltometer (WPI)
Colony counter (Reichert)
Vacuum concentration centrifuge (Thermo electron corp. Savant ISS110-230)
Several mechanical dispersion units (Sonicator/Sonics Vibra Cell VC-505, Homogenizers/Kinematika Ag)
High precision microbalance (Mettler Toledo MX5- Mettler Toledo Plus XP
Low temperature incubator (Raypa)
PH-meter (Mettler Toledo, Seven Multi)
The Laboratory has an up-to-date computer network which includes over sixty personal computers.
Current Research Projects
|GROWTH GRD2-2000–30189||01.11.2001 – 31.10.2005||
Based on 1997 market figures, 60-70% of the 100 million tones of thermoplastic polymeric materials produced worldwide are polyolefins and almost 80% of them are made on supported catalysts. PE and PP represent the 65% of the market of packaging material, 48% of the plastics used by the transportation industry and over 25% of the plastics used in electronic applications. Polyolefins are easy to compose, recycle or dispose. Thus, the continuous improvement of polyolefin properties, will accelerate their growth rate and they will continue to replace other more expensive and polluting polymers. Property improvements, such as higher heat resistance and increased impact strength, coupled with higher flexibility and scratch resistance are some of the direct consequences of the polyPROP project. These, will also lead to improved reactor operation and technology, such as higher catalytic yields, reduced fouling and cleaning, etc.
Despite the economic importance of the production of polyolefins, a significant number of process-related issues remain poorly understood. For example, it is well-known that the rapid process of rupture and expansion of particles during the first seconds of the reaction determines the morphology of the final particles. However, the way that the process and the particles interact needs further investigation. On a larger scale, comprehensive models combing population balances with improved particle models have not yet been able to understand phenomena such as sheeting. The definition of the role of particle morphology, the optimization of polymer properties and the quantification of polymer properties and thermodynamic effects are some of the tasks undertaken by the polyPROP project. On a larger scale, improvements of process operability and the role and optimization of phase changes during the polymerization will be thoroughly investigated.
|GROWTH GRD1-2001–40294||2002 – 2005||
Fluorinated polymers are high-performance, long-lived materials that exhibit outstanding properties and are essential to a great variety of demanding applications. They are produced by conventional homogeneous solution (e.g., in CFCs) and heterogeneous suspension and emulsion (e.g., in aqueous media) polymerization processes. The use of traditional solvents (e.g., CFSs) has prompted considerable worldwide environmental concern that provides the principal driving force which is motivating the development of scCO2 based polymerization technologies. Polymer synthesis in scCO2 can offer significant benefits in terms of process efficiency and product quality. When the environmental advantages of CO2 are combined with its ability to be used as a dispersing medium for a wide variety of fluoropolymers, it becomes clear that CO2 may be the solvent of the future for the fluoropolymer industry.
The programme will address the following research objectives:
- Development of a new generation of polymeric stabilizers (e.g., macromonomers and amphiphatic block and graft copolymers) interfacially active in scCO2 to be used for the formation of stable polymer colloidal dispersions in a CO2 continuous phase.
- Development of novel, cost-effective, environmentally-friendly scCO2 dispersion polymerization processes for the synthesis of a new generation of high-purity and high-performance PVDF and TFE-based copolymers.
- Development of suitable inverse microemulsion environments in scCO2 to be used as polymerization loci for the production of very high molecular weight fluoropolymers having outstanding end-use properties.
- Binary and ternary phase behaviour studies. Solubility and diffusivity measurements. Development of advanced molecular dynamic models.
- Development of advanced mathematical models for the prediction of molecular and morphological properties of fluoropolymers produced in scCO2 processes.
|Research Training Network||01.06.2000 – 31.05.2004||
Market driven flexible, multi-product, batch/semi-batch manufacturing responding rapidly to market needs is becoming increasingly important across the Europe processing industries. This impacts on the growing need for new innovative inter-disciplinary research through the synergy resulting from the bringing together of academic and post doctoral researchers and research students from leading edge academic research groups in the RTN institutions, alongside key end-users and an advanced process control and optimization solution provider.
Specifically, this program aims at the following research objectives.
- The development of integrated optimization, optimizing control and dynamic multivariate statistical performance monitoring procedures for real-time application.
- The development of a range of process modeling tools using computer aided phenomenological, hybrid and data-based empirical modeling approaches; to address the building of generic models for multi-recipe, multi product manufacturing and the issues of model maintenance.
- The harmonious integration of spectroscopic and process measurements together with robust procedures for the state estimation of key state variables.
As the polymer industry becomes more global and competitive pressures are intensifying, European polymer manufacturers recognize that computer modeling is a key enabling technology in dealing with their current urgent needs regarding environment protection, cost reduction, product quality improvement, reduction of time-to-market for new products, improved safety, global operation and competition. The available CAD/CAM software packages for polymerization processes provide little help either because the pertinent process models and computational modules are lacking completely or they are quite simplistic. In response to the current needs of the European Polymer industry, the present proposal aims at the development of a general-purpose prototype software package for simulation, design, parameter and state estimation, optimization and control of polymerization processes (polyPROMS). An open architecture for process modeling environments will be adopted as a means for facilitating the development of model-based applications and as a potential avenue for standardization in modeling technology.
polyPROMS will be used for the full-range of computer-aided process engineering activities including research and development, process engineering, simulation, optimization and control, plant engineering, operator training and troubleshooting bringing significant benefits such as throughput and yield optimization, process troubleshooting and analysis, grade transition strategies, new grade studies, debottlenecking studies, and design of advanced control systems. The new simulator will be easy to use and will not require a highly skilled operating and maintenance staff for plant operations. Thus, polyPROMS can have a significant impact on the European polymer industry in improving productivity, product quality, process safety, and ensuring its sustainable growth.
|GROWTH GRD1-2001–40319||2002 – 2005||
The understanding of the influence of molecular architecture, formulation and processing history on the properties of polymer materials and products is a fundamental question critical to the development of polymer-based products and speciality chemicals. In the present project, a computational design tool is developed to tackle this question in a hierarchical, integrated fashion. This design tool is expected to be used by the European companies in order to overcome existing fundamental limitations inherent in the design of polymer materials and products.
More specifically, the PMILS project addresses the fundamental question of predicting macroscopic properties of polymeric materials from their molecular constitution and processing history. In order to tackle this long-standing problem, a wide range of expertise in modeling tools (quantum mechanical, molecular, mesoscopic, macroscopic) and experimental methods are combined. Essential innovations of the project are: i) organization of these methods in a systematic hierarchical approach and ii) use of integration tools. In particular, the project involves the development of an understanding of the mechanisms responsible for polymer performance using techniques not available in the existing most advanced commercial software packages. This understanding is then applied to a selected set of industrially relevant problems. The main expected result is an integrated design tool for polymer materials able to predict properties from molecular structure and processing history.
|BRITE-ΕURΑΜ, ΒΕ 97-4131||01.03.1998 – 28.02.2002||
The present proposal involves the investigation of the potentialities of the incorporation of polymeric particles and organic molecules into electrolytic zinc coatings produced in continuous coil coating and barrel plating processes on steel. The technical and industrial objectives are the following:
- Development of advanced plating practices to obtain zinc coatings with modified bulk and surface properties.
- Assessment of properties and quality of painted electrogalvanized steel parts (formability, corrosion, paintability) through accelerated laboratory tests and field testing.
- Elimination of environmentally unfriendly pre-treatment processes (e.g., phosphating) presently used to ensure a good paint adhesion onto electrogalvanized steel.
- Achievement of a strong paint adhesion to electrogalvanized steel through chemical bonding reactions between primer or paint of polymeric particles or organic molecules fixed at the surface of the electrolytic zinc.
- Improvement of the corrosion resistance of painted and unpainted electrogalvanized steel through an improved self-passivation of the polymer-containing zinc layer in comparison to current electrodeposited zinc layers.
The NANOCAPS project aims at the development of novel encapsulation technologies for the cost-efficient production of nanoparticles and nanocapsules to be applied in the fields of biomedicine (e.g., encapsulation and controlled release of anti-proliferating and anti-allergic agents) and metal plating (e.g., self-repairable composite zinc and nickel coatings).
The main scientific and technological objectives include:
|GROWTH GRD2-2000–30072||01.10.2001 – 30.09.2005||
The incentive of this project arises from the increasing need for ultra-pure water; this need is dictated by stringent environmental regulations for potable water and by high-standard demands in advanced technological water usage. The objective of the project is to develop hybrid systems, consisting of ceramic or polymeric porous membranes supporting or incorporating organic molecular nanosponge layers. Nanosponges are polymeric materials and their synthesis can be designed for the development of a particular structure, in order to form interior cavities of specific size and chemistry. These cavities can be constructed to have high affinity for organic compounds, therefore novel, tailor-made nanosponge materials can be combined with the appropriate ceramic/polymeric porours material in conventional water purification processes, effectively removing organic contaminants down to ppb concentration levels.In order to achieve this objective the program is divided into the following stages:
- Synthesis and design of novel molecular nanosponges with high affinity, and thus high encapsulation efficiency, to toxic organic contaminants. Focus on synthesis of 3-D crosslinked cyclodextrins, dendrimers, microgels, or hybrid (core-shell) particles, with hydrophobic cavities able to absorb organic compounds in their bulk. Morphological and physicochemical characterization of the materials in order to optimize their performance.
- Development of support materials, appropriate for production of hybrid systems that incorporate nanosponge layers. Development of ceramic membranes with uniform and defect-free nanosponge coating and of hollow- polymeric fibers/nanosponge hybrid membranes.
Design and operation laboratory scale filter systems based on these composite materials as well as scale up to pilot plant operations. Parametric study for process optimization of the hybrid filter system. Evaluation of the composite materials (ceramic/polymeric & nanosponges) of the overall application.
|FP6-2003-NMP-TI-3||2005 – 2008||
The NANOIMPRINT project aims at the development of novel synthesis routes for the production of molecularly imprinted polymers (e.g., nano- and micro-particles and membrane) as well as at the investigation of MIPs for selective recognition and separation of biologically active molecules (e.g., proteins, peptides, oligosaccharide molecules, etc.) and as artificial receptors.
More specifically, the present project addresses the following scientific and technological objectives:
- Development of novel synthesis routes for the economically feasible production of MIPs, taking into account limitations of the current synthetic approaches, and the rational design of improved imprinting materials.
- Development of MIPs for selective recognition and separation of biological materials, utilizing reagents and polymerization techniques for delicate molecules such as oligosaccharides, peptides and for large structures such as proteins.
- Carbohydrate imprinted polymers as enhancers of important bioactive compounds in microbial cultures. MIPs as artificial receptors.
- Development of novel technology for the preparation of artificial receptors with high substrate selectivity and specificity in analytical techniques (immunoassays, chromatography, capillary electrophoresis and solid phase extraction).
- Understanding the mechanisms controlling the molecular structure (e.g., interactions between the template molecule and the polymer matrix) in order to optimize MIPs’ performance.
|FP6-2004-NMP-NI-4||2006 – 2010||
The present IP aims at the development of innovative multidisciplinary approaches for the design, synthesis and evaluation of functionalized nanocarriers and nanoparticle-based microcarriers for the treatment of various diseases based on targeted, controlled delivery of therapeutic peptides and proteins (biopharmaceutics).
More specifically, the present IP aims at the following scientific and technological objectives:
- Design, synthesis and functionalization of novel nanocarriers and nanoparticle-based micro-carriers for targeted delivery of P/P drugs via oral, pulmonary and Blood Brain Barrier (BBB) crossing administration routes.
- Toxicological screening of the nanocarriers and investigation of the release profile of P/P drug under various environmental condi-tions and the assessment of the biocompatibility and biodegradability of the new formulations.
- Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung.
- Oral nanoparticulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties.
- Establishment of an in vitro model for the assessment of nanocarriers permeability through the Blood Brain Barrier (BBB).
|FP6-2004-NMP-NI-4||2006 – 2010||
The present IP aims at the development of novel sustainable bioprocesses for the production of functional, high-added value bioproducts (e.g., lactic acid- and PHA-based polyesters, chitosan and alginate biopolymers, polysaccharide-based biosurfactants) for “niche” applications.
This challenge is expected to be addressed through the following radical innovations:
- Novel biocatalysts: exploration of native/ manipulated micro-organisms for the low-cost production of a wide spectrum of enzymes with tailored substrate specificity, thermal stability and optimum pH. Use of bioinformatics in design of specific enzyme targets.
- Improvement of enzyme stability and catalytic efficiency using immobilization technologies. Bio-catalysis in organic media.
- Metabolic pathway engineering of multiple reactions to generate novel metabolic products, for enhancing naturally occurring pathways to generate intermediates and to broaden the utilizable substrate range to various renewable and waste carbon sources.
- Innovative downstream processing operation for the recovery of bioproducts.
- Digital bioproduction and bioprocessing: the application of advanced modeling, monitoring and control methods to bioprocesses will bring new prospects for substantial improvements in production efficiency and product quality.
Advanced, powerful, flexible, adaptive design software tools are available for the computer aided design, computer aided monitoring, computer-aided optimization and control of a wide-range of industrial polymer production processes. Various polymerization kinetics, reactors and other unit operations can be readily selected and combined to build a process model. Full access to kinetic parameters, species properties and concentrations as well as process conditions is allowed. More specifically, the advanced modeling tools can simulate a wide range of polymerization mechanisms, reaction media and reactor types (e.g., batch, semi-batch and continuous), including:
- High-pressure polyethylene (PE) tubular reactors and autoclaves.
- Polyvinylchloride (PVC) batch suspension polymerization reactors.
- Ziegler-Natta solution and slurry (co)polymerization in tank and loop reactors.
- Catalitic olefin gas-phase copolymerizations in continuous stirred bed reactors and fluidized bed reactors.
The software can be used in a wide range of industrial applications including:
- Analysis of the effect of key process variables on polymer productivity and product quality.
- Examination of process alternatives to increase plant throuput and improve polymer quality.
- Parameter estimation using reaction kinetics data.
- Evaluation of grade transition policies.
- Conducting of safety analysis for reactor runaway conditions.
- Monitoring of important process quality variables using model-based estimators.
- Development of open-loop and closed-loop optimal control policies.
- Training of operators to handle process transitions and equipment failure.
- Computer Aided Design of High Pressure Low Density PolyEthylene Tubular Reactors
- Computer Aided Design of VDF Emulsion Polymerization Reactors
- Polyvinylchloride (PVC) Batch Suspension Polymerization Reactors
The applications performs a simulation of homopolymer grades on a LDPE tubular reactor.
The current version includes the following features:
- Databases for monomers, solvents, initiators thermodynamics, kinetics and transport properties data. The user can enter his own data for any of these parameters (including the kinetic scheme of polymerization).
- Detailed input of all operating conditions of a simulated case, i.e.: a) Type of monomers, solvents, initiator mixtures. b) Conditions and composition of the feedstreams and initiator injection streams. c) Simulation parameters (integration time, etc.) e) Model parameters (fouling factors and initiator efficiencies)
- Values of the various kinetic, heat transfer and transport properties parameters (even editing of the functional relationship of the parameters)
- Additional output options (i.e., generation of reports and output files, export to Excel format, additional options for graphics, etc.)
- Parameter Estimation Module (for the estimation of the time varying model parameters, i.e. initiators efficiency and fouling factors)
|Reactor Configuration||Simulation Results|
The application performs a simulation of VDF Emulsion Polymerization Reactors
|Reactor Configuration||Simulation Results|
- The present CAD simulation tool is based on state-of-the-art mathematical models capable to quantitatively describe the various chemical and physical phenomena occurring in different modeling levels in the polymerization reactor. The application is used for the simulation, optimization and control of industrial polyvinylchloride (PVC) batch suspension polymerization reactors.
The current version includes the following features:
- Databases for monofunctional and bifunctional initiators, inhibitors and kinetic data.
- The user-engineer can enter his own data for any of these parameters including the kinetic scheme of polymerization.
- Full access to kinetic parameters, species properties, species concentrations and process conditions.
- Detailed input of all operating conditions, i.e., a) type of initiator mixtures, b) conditions and composition of the feed streams and initiator injection streams, c) simulation parameters (e.g., integration time), d) type of batch reactor (e.g., laboratory, pilot plant, industrial), e) reactor geometry, overhead condenser design characteristics and control scheme.
The CAD software tool is capable of predicting:
a) The overall monomer conversion and polymerization rate.
b) The dynamic evolution of the polymer structural characteristics (i.e., molecular weight distribution and number and weight average molecular weights, long-chain branching, short-chain branching, terminal double bonds, particle size distribution and the morphology/porosity of the polymer particles).
c) The reactor and condenser temperatures and jacket inlet and outlet temperatures over the whole polymerization cycle.
d) The reactor pressure and monomer distribution in monomer, polymer, gas and aqueous phases.
Useful information about the polymer productivity, energy required, molecular and morphological characteristics of the PVC produced, is available to the user-engineer through multiple comparative graphs…
…or through report files that can be exported to Microsoft Excel:
The user-engineer is able to compare simulation results with experimental data on laboratory or industrial batch suspension PVC polymerization reactors which can be imported as excel files in the software package:
Software Application And Benefits
The software makes it possible to simulate polymer processes in a simple and straightforward manner bringing significant business benefits to a polymer producer, including:
- Throuput and Yield Optimization: Maximize the production rate for each polymer grade and minimize the formation of byproducts.
- Process Troubleshooting and Analysis: Models can be used to pinpoint process and equipment problems. They will also help engineers to understand process-product quality relationship and troubleshoot product quality problems.
- Grade Transition Strategies: Develop grade transition strategies that will minimize the transition time and the amount of off-spec polymer.
- New Grade Studies: Perform ‘process test runs’ with polymer models to develop new polymer grades, thus minimizing the number of pilot and plant trials.
- Debottlenecking Studies: Analyze current process bottlenecks and assist in scale-up of existing polymer lines including reactor modifications, etc.
- Design Advanced Control Systems: Polymer models can be used to support the development/implementation ofadvanced process control.
- Debottlenecking Studies: Analyze current process bottlenecks and assist in scale-up of existing polymer lines including reactor modifications, etc.
- Design Advanced Control Systems: Polymer models can be used to support the development/implementation of advanced process control.
The new simulator is easy to use and does not require highly skilled personnel.
Mathematical modeling of the BORSTAR fluidized bed reactor.
Mathematical modelling of high pressure ethylene - vinyl acetate tubular reactors.
Theoretical and experimental investigation of emulsion polymerization of VCM. Modeling and simulation of vinylidene fluoride polymerization in supercritical carbon dioxide.
Theoretical and experimental investigation of suspension polymerization of VCM. Modeling of particle size distribution and rheological properties of acrylic latexes in emulsion polymerization reactors. Modelling and simulation of vinylidene fluoride batch emulsion polymerization. Computer aided design of industrial poly (vinyl chloride) batch suspension polymerization reactors.
Confinement of selected actives into novel microencapsulation systems.
- Agallou M., Athanasiou E., Kammona O., Tastsoglou S., Hatzigeorgiou A.G., Kiparissides C., Karagouni E., "Transcriptome analysis identifies immune markers related to visceral leishmaniasis establishment in the experimental model of BALB/c mice", Frontiers in Immunology, 10, article 2749</li
- Tsanaktsidou E., Kammona O., Kiparissides C., "On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions", European Polymer Journal 114, 47-56
- Pladis P., Kiparissides C., "110th Anniversary: Nonideal Mixing Phenomena in High-Pressure Low-Density Polyethylene Autoclaves: Prediction of Variable Initiator Efficiency and Ethylene Decomposition", Industrial & Engineering Chemistry Research 58 (29), 13093-13111
- Kiparissides C., Alexopoulos AH, Karageorgos P., Vasileiadou A., Bourganis V., “A Process System Approach to Nose-to-Brain Delivery of Biopharmaceutics“, Computer Aided Chemical Engineering 43, 1661-1666, (2018)
- Chrysikou L., Bezergianni S., Kiparissides C., “Environmental Analysis of a Lignocellulosic-based Biorefinery Producing bioethanol and High-added Value Chemicals”, Sustainable Energy Technologies and Assessments, 28, 103–109, (2018)
- Pladis P., Baltsas A, Meimaroglou D. and Kiparissides C., “A Dynamic Simulator for Slurry-phase Catalytic Olefin Copolymerization in a Series of CSTRs: Prediction of Distributed Molecular and Rheological Properties”, Macromolecular Reaction Engineering, (Special Issue "Dedicated to Hamielec, Ray, Cozewith"), 1800017, (2018)
- Bourganis V., Kammona O., Alexopoulos A. and Kiparissides C., “Recent Advances in Carrier Mediated Nose-to-Brain Delivery of Pharmaceutics“, European Journal of Pharmaceutics and Biopharmaceutics, 128, 337-362, (2018)
- Penloglou G., Chatzidoukas C., Kiparissides C., “Scale-up and intensification of a microalgae cultivation process for the production of high-added value biochemicals“, Materials Today: Proceedings, 5(14), 27463–27471, 2018
- Alexopoulos AH, Kiparissides C.,“A Computational Model for the Analysis of Spreading of Viscoelastic Droplets over Flat Surfaces“, Fluids, 3(4), 78, 2018
- Pladis P., Baltsas A., Kiparissides C., “A Comprehensive Model for the Simulation of Ethylene Decomposition in High-Pressure LDPE Autoclaves”, Computer Aided Chemical Engineering, 40, 337-342, (2017)
- Penloglou G., Vasileiadou A., Chatzidoukas C., Kiparissides C., “Model-based intensification of a fed-batch microbial process for the maximization of polyhydroxybutyrate (PHB) production rate”, Bioprocess and Biosystems Engineering, 40(8), 1247-1260, (2017)
- Margaroni M., Agallou M., Athanasiou E., Kammona O., Kiparissides C., Gaitanaki C., Karagouni E., “Vaccination with poly(D,L-lactide-co-glycolide) nanoparticles loaded with soluble Leishmania antigens and modified with a TNFα-mimicking peptide or monophosphoryl lipid A confers protection against experimental visceral leishmaniasis”, International Journal of Nanomedicine, 12, 6169–6184, (2017)
- Athanasiou E., Agallou M., Tastsoglou S., Kammona O., Hatzigeorgiou A., Kiparissides C., Karagouni E., “A Poly(Lactic-co-Glycolic) Acid Nanovaccine Based on Chimeric Peptides from Different Leishmania infantum Proteins Induces Dendritic Cells Maturation and Promotes Peptide-Specific IFNγ-Producing CD8+ T Cells Essential for the Protection against Experimental Visceral Leishmaniasis”, Frontiers in Immunology - Vaccines and Molecular Therapeutics, Vol 8, Article 684, (2017)
- Kammona O., Bourganis V., Karamanidou T., Kiparissides C., "Recent Developments in Nanocarrier-Aided Mucosal Vaccination", Nanomedicine, 12(9), 1057-1074, (2017)
- Agallou M., Margaroni M., Athanasiou E., Toubanaki D., Kontonikola K., Karidi K., Kammona O., Kiparissides C., Karagouni, E., "Identification of BALB/c Immune Markers Correlated with a Partial Protection to Leishmania infantum after Vaccination with a Rationally Designed Multi-epitope Cysteine Protease A Peptide-based Nanovaccine", PLOS Neglected Tropical Diseases, 11(1), e0005311, (2017)
- Milenkovic J., Alexopoulos A., Kiparissides C., “Optimization of a DPI Inhaler: A Computational Approach”, Journal of Pharmaceutical Sciences, 106(3), 850–858, (2017)
- Bourganis V., Karamanidou T., Kammona O., Kiparissides C., "Polyelectrolyte Complexes as Prospective Carriers for the Oral Delivery of Protein Therapeutics", European Journal of Pharmaceutics and Biopharmaceutics, 111, 44–60, (2017)
- Karapatsia Α., Pappas Ι., Penloglou G., Kotrotsiou O., Kiparissides C., "Optimization of Dilute Acid Pretreatment and Enzymatic Hydrolysis of Phalaris aquatica L. Lignocellulosic Biomass in Batch and Fed-batch Processes", BioEnergy Research, 10, 225-236, (2017)
- Penloglou G., Vasileiadou A., Chatzidoukas C., Kiparissides C., “Model-based Intensification of the Fed-batch Microbial Process for the Production of Polyhydroxybutyrate (PHB) with Maximum Rate”, submitted to Bioprocess and Biosystems Engineering, 2016
- Bezergianni S., Chrysikou L., Kiparissides C., “Environmental analysis of a lignocellulosic-based biorefinery producing bioethanol and high-added value chemicals” submitted to Environmental Management, (2016)
- Karamanidou T., Bourganis V., Kammona O., Kiparissides C., "Lipid-based Nanocarriers for the Oral Administration of Biopharmaceutics", Nanomedicine, 11(22), 3009-3032, (2016)
- Malsch I., Rutkowska-Zbik D., Himly M., Kiparissides C., Kammona O., Szafran B., Lynch I., Ntow F., “Current Trends in Nanoeducation for Industry and Society”, Current Bionanotechnology, 2, 112-115, (2016)
- Meimaroglou D., Pladis P., Kiparissides C., “Dynamic Monte Carlo Simulation of the l,l-Lactide Ring-Opening Polymerization“, Macromolecular Reaction Engineering, (2016), DOI: 10.1002/mren.201600039
- Margaroni M., Agallou M., Kontonikola K., Karidi K., Kammona O., Kiparissides C., Gaitanaki C., Karagouni E., “PLGA Nanoparticles Modified with a TNF Mimicking Peptide, Soluble Leishmania Antigens and MPLA Induce T Cell Priming in Vitro via Dendritic Cell Functional Differentiation”, European Journal of Pharmaceutics and Biopharmaceutics, 105, 18–31, (2016)
- Malsch I., Rutkowska-Zbik D. , Duschl A., Himly M., Zadrozny Th., Kiparissides C., Kammona O., Talesnik M., Rothschild Y., Rosenberg D., Szafran B., Rodriguez P.Q., and Lynch I. Chapter 6: “Nanoeducation for Industry and Society“, Springer - Managing Risk in Nanotechnology, Topics in Governance, Assurance and Transfer, 93-115, (2016)
- Karapatsia A., Penloglou G., Chatzidoukas Ch., Kiparissides C., “Fed-batch Saccharomyces Cerevisiae Fermentation of Hydrolysate Sugars: A Dynamic Model-based Approach for High Yield Ethanol Production”, Biomass and Bioenergy, 90, 32-41, (2016)
- Karapatsia A., Penloglou G., Chatzidoukas Ch., Kiparissides C., “An Experimental Investigation of Stichococcus Sp. Cultivation Conditions for Optimal Co-Production of Carbohydrates, Proteins and Lipids Following a Biorefinery Concept”, Biomass and Bioenergy, 89, 123-132, (2016)
- Gkementzoglou Ch., Kotrotsiou O., Koronaiou M., Kiparissides C., “Development of a Sandwich-type Filtration Unit Packed with MIP Nanoparticles for Removal of Atrazine from Water Sources”, Chemical Engineering Journal, 287, 233–240, (2016)
- Bode GH, Pickl KE, Sanchez-Purrà M., Albaiges B, Borrós S., Pötgens A., Schmitz Ch., Frank M. Sinner FM, Losen M., Steinbusch H., Frank HG, Martinez-Martinez P., Wagemann, K., Klok, H.-A., Unger, R.E., Pieber, T., Cesaro, A., Engbersen, J., Kasemo, B., Moeller, M., Korenstein, R., Grandfils, C., Bernkop-Schnuerch, A., Kiparissides, C., Slomkowski, s., Venturini, P., Paleos, C.M., Podobnik, B., Borm, P., Van Winden, E.C.A., Groll, J., Zassler, B., Gregoriadis, G., Nielsen, P.K., Elouahabi, A., "Detection of Peptide-Based Nanoparticles in Blood Plasma by ELISA", PloS ONE, 10 (5), art. no. e0126136, (2015)
- Karapatsia A., Penloglou G., Chatzidoukas C., Kiparissides C., “Development of a Macroscopic Model for the Production of Bioethanol with High Yield and Productivity via the Fermentation of Phalaris aquatica L. Hydrolysate“, Computer Aided Chemical Engineering, 37, 2129-2134, (2015)
- Karamanidou Th., Karidi K, Bourganis V., Kontonikola K., Kammona O., Kiparissides C., “Effective Incorporation of Insulin in Mucus Permeating Self-Nanoemulsifying Drug Delivery Systems”, European Journal of Pharmaceutics and Biopharmaceutics, 97, 223-229, (2015)
- Karidi K., Mantourlias Th., Seretis A., Pladis P. and Kiparissides C., “Synthesis of High-Molecular Weight Linear and Branched Polylactides: A Comprehensive Kinetic Investigation” European Polymer Journal, 72, 114-128, (2015)
- Dünnhaupt S., Kammona O., Waldner C., Kiparissides C. and Bernkop-Schnürch A., “Nano-carrier systems: Strategies to overcome the mucus gel barrier”, European Journal of Pharmaceutics and Biopharmaceutics, 97, 447-453, (2015)
- Bourganis V., Karamanidou Th., Samaridou E., Karidi K., Kammona O. and Kiparissides C., “On the Synthesis of Mucus Permeating Nanocarriers”, European Journal of Pharmaceutics and Biopharmaceutics, 97, 239-249, (2015)
- Pladis P., Meimaroglou D. and Kiparissides C., “Prediction of the Viscoelastic Behaviour of Low-density Polyethylene Produced in High-Pressure Tubular Reactors”, Macromolecular Reaction Engineering, 9(3), 271–284, (2015)
- Karakosta, P., Alexopoulos, A. and Kiparissides, C., “Computational Model of Particle Deposition in the Nasal Cavity under Steady and Dynamic Flow”, Computer Methods in Biomechanics and Biomedical Engineering, 18(5), 514-526, (2015)
- Kiparissides, C., Kammona, O., "Nanotechnology Advances in Diagnostics, Drug Delivery and Regenerative Medicine", Fecht, Werner, Van de Voorde (Eds.): The Nano-Micro Interface. Bridging the Micro and Nano Worlds, 2/e, to be published by Wiley-VCH Verlag GmbH & Co. KGaA. (Chapter)
- Samaridou E., Karidi K., Pereira de Sousa I., Cattoz B., Griffiths P., Kammona O., Bernkop-Schnürch A. and Kiparissides C., “Enzyme Functionalized PLGA Nanoparticles with Enhanced Mucus Permeation Rate”, Nano LIFE, 4(4), 1441013, (2014)
- Pladis P., Karidi K., Mantourlias Th., and Kiparissides C., “An Experimental and Theoretical Investigation of the Ring-Opening Polymerization of L,L-Lactide”, Macromolecular Reaction Engineerin, 8(12), 813-825, (2014)
- Karapatsia A., Penloglou G., Pappas I. and Kiparissides C., “Bioethanol Production via the Fermentation of Phalaris Aquatica L. Hydrolysate”, Chemical Engineering Transactions, 34, 289, (2014)
- Pladis, P., Alexopoulos, A. and Kiparissides, C., “Mathematical Modelling and Simulation of Vinylidene Fluoride Emulsion Polymerization”, Industrial & Engineering Chemistry Research, 53, 7352−7364, (2014)
- Meimaroglou, D., Kiparissides, C., “A Review of Monte Carlo Methods for the Prediction of Distributed Molecular & Morphological Polymer Properties”, Industrial & Engineering Chemistry Research, 53, 8963−8979, (2014)
- Pladis, P., Baltsas, A., Kanellopoulos, V., and Kiparissides, C., “Dynamic Multi-phase, Multi-zone Modeling of Flash Separators for Highly-Viscous Polymerization Processes”, Macromolecular Reaction Engineering, 8, 392–405, (2014)
- Milenkovic, J., Alexopoulos, A. and Kiparissides, C., “Airflow and Particle Deposition in a Dry Powder Inhaler. An Integrated CFD Approach”, Simulation and Modeling Methodologies, Technologies and Applications, Advances in Intelligent Systems and Computing 256, 127-140, (2014)
- Milenkovic, J., Alexopoulos, A. and Kiparissides, C., “Deposition and Fine Particle Production during Dynamic Flow in a Dry Powder Inhaler: A CFD Approach”, International Journal of Pharmaceutics, 461 (1–2), 129-136, (2014)
- Najafi, M., Parvazinia, M., Ghoreishy, M.H.R. and Kiparissides, C., “Development of a 2-D Dynamic Particle Growth Model to Analyze the Effects of Initial Catalyst Shape and Size in Ziegler-Natta Olefin Polymerisation”, Macromolecular Reaction Engineering, 8 (1), 29–45, (2014)
- Karidi, K., Pladis, P. and Kiparissides, C., “A Theoretical and Experimental Kinetic Investigation of the ROP of L,L-Lactide in the Presence of a Polyalcohol”, Macromolecular Symposia, 333, 206-215, (2013)
- Kiparissides, C. and Kammona, O. “Nanoscale Carriers for Targeted Delivery of Drugs and Therapeutic Biomolecules”, Canadian Journal of Chemical Engineering, 91, 638-561, (2013)
- Κarakosta, P., Koumlili, E., Kammona, O. and Kiparissides, C., “Antimicrobial Agent-Containing Polymeric Materials”, Macromolecular Symposia, 331-332, 144-151, (2013)
- Gkementzoglou Ch, Kotrotsiou O., Stoukides M. and Kiparissides C., “On the Synthesis of Molecularly Imprinted Polymersfor Analytical and Sensor Applications”, Macromolecular Symposia, 331-332, 26-33, 2013
- Gkementzoglou, Ch, Kotrotsiou, O. and Kiparissides, C., “Synthesis of Novel Composite Membranes Based on Molecularly Imprinted Polymers for Removal of Synthetic Organic Compounds from Water”, Industrial & Engineering Chemistry Research, 52, 14001−14010, (2013)
- Milenkovic, J., Alexopoulos, A. H. and Kiparissides, C., “Flow and Particle Deposition in the Turbuhaler. A CFD Simulation”, International Journal of Pharmaceutics, 448, 205– 213, (2013)
- Chatzidoukas Ch., Penloglou G., Kiparissides C., "Development of a Structured Dynamic Model for the Production of Polyhydroxybutyrate (PHB) in A. Lata Cultures", Biochemical Engineering Journal, 71, 72– 80 (2013)
- Kiparissides, C. and Kammona, O. “Nanoscale Carriers for Targeted Delivery of Drugs and Therapeutic Biomolecules”, Canadian Journal of Chemical Engineering, 91, 638-651, (2013)
- Penloglou, G., Chatzidoukas, Ch. and Kiparissides, C., “Microbial production of polyhydroxybutyrate with tailor-made properties: An integrated modelling approach and experimental validation”, Biotechnology Advances, 30, 329–337 (2012)
- Penloglou G. Kretza E., Chatzidoukas Ch., Parouti, S., Kiparissides, C. “On the Control of Molecular Weight Distribution of Polyhydroxybutyrate in Azohydromonas lata Culutres”, Biochemical Engineering Journal, 62, 39– 47 (2012)
- Roussos, A. and Kiparissides, C., “A Bivariate PBE Approach for the Description of Microbial PHB Production Processes”, Chemical Engineering Science, 70, 45–53 (2012)
- Kechagia Z., Pladis P., Kammona O., Alexopoulos A. and Kiparissides C. “A Kinetic Investigation of Removal of Residual Monomers from Polymer Latexes via Post-Polymerization and Nitrogen Stripping Methods”, Macromolecular Reaction Engineering 5(9-10), P: 479–489 (2011)
- Meimaroglou, D., Pladis, A., Baltsas, A. and Kiparissides, C. “Prediction of the Molecular and Polymer Solution Properties of LDPE in a High-Pressure Tubular Reactor Using a Novel Monte Carlo Approach”, Chemical Engineering Science, 66(8), 1685-1696 (2011)
- Sarti F., Perera G., Hintzen F., Kotti K., Karageorgiou V., Kammona O., Kiparissides C., Bernkop-Schnurch A., “In Vivo Evidence of Oral Vaccination with PLGA Nanoparticles Containing the Immunostimulant Monophosphoryl Lipid A”, Biomaterials, 32 (16), 4052-4057 (2011)
- Kammona, O., Alexopoulos, A.H., Karakosta, P., Kotti, K., Karageorgiou, V. and Kiparissides, C., “Nanocarrier Aided Nasal Vaccination: An Experimental and Computational Approach”, Industrial & Engineering Chemistry Research, 50 (2), 590–601, (2011)
- Kiparissides C., Krallis A., Meimaroglou D., Pladis P., and Baltsas A., “From Molecular to Plant Scale Modeling of Polymerization Processes: A Digital High-Pressure LDPE Production Paradigm”, Chem. Eng. Technol, 33 (11), 1754–1766 (2010)
- Meimaroglou, D. and Kiparissides, C. “A Novel Stochastic Approach for the Prediction of the Exact Topological Characteristics of Highly-Branched Polymers” Macromolecules, 43, 5820–5832 (2010)
- Penloglou, G., Roussos, A., Chatzidoukas, Ch., and Kiparissides, C., “A Combined Metabolic/Polymerization Kinetic Model on the Microbial Production of Poly(3-hydroxybutyrate)”, New Biotechnology, 27(4), 358-367, (2010)
- Kotti, K and Kiparissides, C., “Synthesis of Composite Polystyrene/Silica Nanoparticles via Precipitation and Emulsion Polymerization Methods”, Macromol. React. Eng., 4(5), 347-357 (2010)
- Krallis, A., Pladis, P., Kanellopoulos and Kiparissides, C. “Development of Advanced Computer-Aided Software Tools for Design, Simulation and Optimization of Polymerization Processes”, Macromol. React. Eng., 4(5), 303-308, (2010)
- Touloupides, V., Kanellopoulos, V., Pladis, P. and Kiparissides, C., “Modeling and Simulation of Industrial Slurry-Phase Catalytic Olefin Polymerization Reactors Series”, Chemical Engineering Science, 65(10), 3208-3222 (2010)
- Kotrotsiou, O., Chaitidou, S. and Kiparissides, C., “Boc-L-Tryptophan Imprinted Polymeric Microparticles for Bioanalytical Applications”, Materials Science & Engineering C 29(7), 2141-2146, (2009)
- Katsikari, A., Patronidou, Chr., Kiparissides, C. and Arsenakis, M., “Uptake and Cytotoxicity of Poly(D,L-Lactide-Co-Glycolide) Nanoparticles in Human Colon Adenocarcinoma Cells”, Materials Science & Engineering B, 165(3), 15, 160-164, (2009)
- Alexopoulos, A.H., Roussos, A. and Kiparissides, C., “Part V: Dynamic Evolution of the Multivariate Particle Size Distribution Undergoing Combined Particle Growth and Aggregation”, Chemical Engineering Science 64, 3260—3269, (2009)
- Chaitidou, S., Kotrotsiou, O. and Kiparissides, C., “On the Synthesis and Rebinding Properties of [Co(C2H3O2)2(z-Histidine)] Imprinted Polymers Prepared by Precipitation Polymerization”, Materials Science & Engineering C, 29, 1415-1421, (2009)
- Kammona, O., Kotti, K., Kiparissides, C., Fransaer, J. and Celis, J.-P., “Synthesis of Polymeric and Hybrid Nanoparticles for Electroplating Applications”, Journal of Electrochimica Acta, 54, 2450, (2009)
- Chatzidoukas, Ch., Pistikopoulos, E. and Kiparissides C., “A Hierarchical Optimisation Approach to Optimal Production Scheduling in an Industrial Continuous Olefin Polymerization Reactor”, Macromolecular Reaction Engineering, 3, 36 (2009)
- Kotrotsiou, O., Chaitidou, S. and Kiparissides, C., “On the Synthesis of Peptide Imprinted Polymers by a Combined Suspension - Epitope Polymerization Method”, Materials Science & Engineering B, 165(3), 15, 256-260 (2009)
- Krallis, A. and Kiparissides, C., “Computer Aided Design and Operation of Industrial Poly(Vinyl Chloride) Batch Suspension Polymerization Reactors”, Plastics, Rubber and Composites: Macromolecular Engineering (PRC:ME), 37, 436,(2008)
- Saliakas, V., Kotoulas, C., Meimaroglou, D. and Kiparissides, C. “Dynamic Evolution of the Particle Size Distribution in Suspension Polymerization Reactors: A Comparative Study on Monte Carlo and Sectional Grid Methods”, Canadian Journal of Chemical Engineering, 86, 924 (2008)
- Patronidou, C., Karakosta, P., Kotti, K., Kammona, O., Karageorgiou, V. and Kiparissides, C., “PLGA nanocarriers for systemic and lymphatic oral delivery of proteins and peptides”, Journal of Controlled Release, 132(3), e5-e6, (2008)
- Pladis, P, Kanellopoulos, V., Chatzidoukas, Ch. and Kiparissides, C., “Effect of Reaction Conditions and Catalyst Design on the Rheological Properties of Polyolefins Produced in Gas-phase Olefin Polymerization Reactors”, Macromolecular Theory and Simulation, 17, 478-487 (2008)
- Chaitidou, S., Kotrotsiou, O., Kotti, K., Kammona, O., Bukhari, M. and Kiparissides, C. “Precipitation Polymerization for the Synthesis of Nanostructured Particles”, Materials Science and Engineering B', 152, 55-59 (2008)
- Kiparissides, C. and Kammona, O. “Nanotechnology Advances in Controlled Drug Delivery Systems”, Physica Status Solidi, (c) 5, No. 12, 3828-3833 (2008)
- Meimaroglou, D., Krallis, A. and Kiparissides, C., “Prediction of Bivariate Molecular Property Distributions in Free-Radical Polymerization Systems Using Monte Carlo and Sectional Grid Methods”, Chemical Product and Process Modeling, vol. 3, iss. 1, article 44, CAPE Special Issue, (2008)
- Krallis, A., Meimaroglou, D. and Kiparissides, C., “Dynamic Prediction of the Bivariate Molecular Weight – Copolymer Composition Distribution Using Sectional-Grid and Stochastic Numerical Methods”, ChemEngiSci, 63, 4342-4360 (2008)
- Kanellopoulos, V., Gustafsson, B. and Kiparissides, C., “Gas-phase Olefin Polymerization in the Presence of Supported and Self-supported Ziegler-Natta Catalysts”, Macromolecular Reaction Engineering, 2, 240-252 (2008)
- Kechagia, Z., Kiparissides, C. and Economou, I., “Determination of Liquid-Gas Partition Coefficients of Bua and MMA by Headspace-Gas Chromatography Utilizing the Phase Ratio Variation Method”, Fluid Phase Equilibria 266, 21-30, (2008)
- Kammona, O., Dini, E., Kiparissides, C. and Allabashi, R., “Synthesis of Polymeric Porous Microparticles for Water Purification”, Microporous and Mesoporous Materials 110, (1), 141-149, (2008)
- Dompazis, G., Kanellopoulos, V., Touloupides, V. and Kiparissides, C., “Development of a Multi-scale, Multi-phase, Multi-zone Dynamic Model for the Prediction of Particle Segregation in Catalytic Olefin Polymerization FBRs”, Chemical Engineering Science, 63, 4735-4753 (2008)
- Kotti, K., Kammona, O. and Kiparissides, C., “Synthesis of Polymer-Silica Composite Nanoparticles For Electroplated Coatings”, Journal of Nanostructured Polymers and Nanocomposites, 3, 75-81 (2007)
- Kotrotsiou, O., Chaitidou, S., Liakopoulou-Kyriakides, M. and Kiparissides, C., “Molecularly Imprinted Polymers for Selective Recognition of Biomolecules”, Journal of Nanostructured Polymers and Nanocomposites, 3, 35-45 (2007)
- Chatzidoukas, C., Kanellopoulos, V. and Kiparissides, C., “On the Production of Polyolefins with Bimodal Molecular Weight and Copolymer Composition Distributions in Catalytic Gas-phase Fluidized Bed Reactors”, Macromolecular Theory & Simulations, 16, 755-769 (2007)
- Kotoulas, C. and Kiparissides, C., “Polymer Reaction Engineering, Chapter 5. Suspension Polymerization”, Blackwell Publishing Ltd, 209-230, (2007)
- Meira, G. R. and Kiparissides, C., “Polymer Reaction Engineering, Chapter 4. Free Radical Polymerization: Heterogeneous Systems”, Blackwell Publishing Ltd, 179-206, (2007)
- Krallis, A., Pladis, P. and Kiparissides, C., “Prediction of the Bivariate Molecular Weight – Long Chain Branching Distribution in High – Pressure Low – Density Polyethylene Autoclaves”, Macromolecular Theory & Simulations, 16, 593-609, (2007)
- Krallis, A. and Kiparissides, C., “Mathematical Modeling of the Bivariate Molecular Weight – Long Chain Branching Distribution of Highly Branched Polymers. A Population Balance Approach”, Chem Eng Sci, 62, 5304-5311, (2007)
- Meimaroglou, D and Kiparissides, C., “Monte Carlo Simulation for the Solution of the Bi-Variate Dynamic Population Balance Equation in Batch Particulate Systems”, Chem Eng Sci, 62, 5295-5299, (2007)
- Alexopoulos, A. and Kiparissides, C., “Solution of the Bivariate Dynamic Population Balance Equation in Batch Particulate Systems: Combined Aggregation and Breakage”, Chem. Eng. Sci., 62, 5048-5043 (2007)
- Alexopoulos, A. and Kiparissides, C., “On the prediction of internal particle morphology in suspension polymerization of vinyl chloride. Part I: The effect of primary particle size distribution”, Chem. Eng. Sci., 62(15), 3970-3983, (2007)
- Meimaroglou D., Krallis, A., Saliakas, V. and Kiparissides, C., “Prediction of the Bivariate Molecular Weight - Long Chain Branching Distribution in Highly Branched Polymerization Systems Using Monte Carlo and Sectional Grid Methods” , Macromolecules 40(6), 2224-2234, (2007)
- Kanellopoulos, V., Tsiliopoulou, E., Dompazis, G., Touloupides, V. and Kiparissides, C. “Evaluation of the Internal Particle Morphology in Catalytic Gas-Phase Olefin Polymerization Reactors”, Ind. & Eng. Chem. Res, 46(7), 1928-1937, (2007)
- Saliakas, V., Chatzidoukas, C., Meimaroglou, D., Krallis, A. and Kiparissides, C., "Dynamic Optimization of Molecular Weight Distribution Using Orthogonal Collocation on Finite Elements and Fixed Pivot Methods: An Experimental and Theoretical Investigation", Macromol. React. Eng. 1(1), 119-136, (2007)
- Kanellopoulos, V., Mouratides, D., Tsiliopoulou, E. and Kiparissides, C., "An Experimental and Theoretical Investigation on the Diffusion of Olefins in Semi-Crystalline Polymers: The Influence of Swelling in Polymer-Penetrant Systems", Macromol. React. Eng.1(1), 106-118, (2007)
- A.I. Roussos, A.H. Alexopoulos, and C. Kiparissides, “Part III: Dynamic Evolution of the Particle Size Distribution in Batch and Continuous Particulate Processes: A Galerkin on Finite Elements Approach”, Chem. Eng. Sci, 60(24), 6998 (2005)
- Dompazis, G., Kanellopoulos, V. and Kiparissides, C., “A Multi-scale Modeling Approach for the Prediction of Molecular and Morphological Properties in Multi-site Catalyst Olefin Polymerization Reactors”, Macromol Mater Eng, 290, 525–536 (2005)
- Alexopoulos, A.H. and Kiparissides, C.“Part II: Dynamic Evolution of the Particle Size Distribution in Particulate Processes Undergoing Simultaneous Particle Nucleation, Growth and Aggregation”, Chem Eng Sci, 60, 4157 (2005)
- C. Kiparissides, A. Baltsas, E. Papadopoulos, J. P. Congalidis, J. R. Richards, M. B. Kelly and Y. Ye, “Mathematical Modeling of LDPE Copolymers in High - Pressure Tubular Reactors”, Ind. & Eng. Chem. Res., 44, 2592 (2005) (Special Issue, in honor H.W.Ray)
- Kotrotsiou Ο., Kotti K., Dini E., Kammona Ο. and Kiparissides C. “Nanostructured Materials for Selective Recognition and Targeted Drug Delivery”, Journal of Physics: Conference Series, 10, 281–284 (2005)
- Karayiannis, N., Mavrantzas, V., Mouratides, D., Chiotellis, E. and Kiparissides, C., "Chapter 6: Atomistic molecular dynamics simulation of short-chain branched polyethylene melts", Elsevier: Multiscale Modelling of Polymer Properties (2006)
- Kiparissides C., Pladis P. and Moen O., "Chapter 3: From polyethylene rheology curves to molecular weight distributions", Elsevier: Multiscale Modelling of Polymer Properties (2006)
- Kanellopoulos, V., Mouratides, D., Pladis, P. and Kiparissides, C., “Prediction of Solubility of α-Olefins in Polyolefins Using a Combined Equation of State - Molecular Dynamics Approach”, Ind. & Eng. Chem. Res, 45, 5780, (2006)
- Dompazis, G., Kanellopoulos, V. and Kiparissides, C., “Assessment of Particle Agglomeration in Catalytic Olefin Polymerization Reactors Using Rheological Measurements”, Ind. & Eng. Chem. Res, 45(11), 3800 (2006)
- Meimaroglou, D., Roussos, A.I. and Kiparissides, C. “Part IV: Dynamic Evolution of the Particle Size Distribution in Particulate Processes. A Comparative Study between Monte Carlo and the Generalized Method of Moments”, Chem Eng Sci, 61, 5620 (2006)
- Kotoulas, C. and Kiparissides, C., “A Generalized Population Balance Model for the Prediction of Particle Size Distribution in Suspension Polymerization Reactors”, Chem. Eng. Sci, 61, 332 (2006)
- Kiparissides, C.“Challenges in Polymerization Reactor Modeling and Optimization: A Population Balance Perspective”, J Proc Contr, 16, 205-224 (2006)
- Roussos, A.I., Alexopoulos, A.H. and Kiparissides, C. “Dynamic Evolution of PSD in Continuous Flow Reactos: A Comparative Study of Fixed and Moving Grid Numerical Techniques”, Chem Eng Sci, 61, 124 (2006)
- Kiparissides, C., Alexandridou, S., Kotti, K. and Chaitidou, S., “Recent Advances in Novel Drug Delivery Systems”, Journal of Nanotechnology online, 2, 1-11, (2006)
- C. Kiparissides, A Alexopoulos, A. Roussos, G. Dompazis, and C. Kotoulas, “Population Balance Modeling of Particulate Polymerization Processes”, Ind. & Eng. Chem. Res., 43(23), 7290 (2004)
- A.H. Alexopoulos, A.I. Roussos, and C. Kiparissides, “Part I: Dynamic Evolution of the Particle Size Distribution in Particulate Processes Undergoing Combined Particle Growth and Aggregation”, Chem Eng Sci, 59, 5751 (2004)
- A. Krallis, C. Kotoulas, E. Papadopoulos, C. Kiparissides, J. Bousquet and C. Bonardi, “A Comprehensive Kinetic Model for the Free-Radical Polymerization of Vinyl Chloride Initiated by Mixture of Monofunctional and Bifunctional Initiators” Ind. & Eng. Chem. Res., 43(20), 6382 (2004)
- Kanellopoulos,V., Dompazis, G., Gustafsson, B. and Kiparissides C., “A Comprehensive Analysis on Single Particle Growth in Heterogeneous Olefin Polymerization: The Random Pore Polymeric Flow Model”, Ind. & Eng. Chem. Res., 43(17), 5166 (2004)
- Assimopoulou AN, Papageorgiou VP, Kiparissides C, “Synthesis and Release Studies of Shikonin-Containg Microcapsules Prepared by the Solvent Evaporation Method”, J Microencapsul, 20(5), 581-596 (2003)
- C. Chatzidoukas, J.D. Perkins, E.N. Pistikopoulos and C. Kiparissides, “Optimal Grade Transition and Selection of Feedback Control Loops in a Gas-Phase Polyolefin FBR using a Mixed Integer Dynamic Optimisation Approach”, Chem Eng Sci, 58, 3643-3685 (2003)
- Parouti, S., Kammona, O., Kiparissides, C. and Bousquet, J., “A Comprehensive Experimental Investigation of the Methyl Methacrylate/Butyl Acrylate/Acrylic Acid Emulsion Terpolymerization”, Polymer Reaction Engineering, 11(4), 829-853 (2003)
- Kammona, O., Pladis, P., Frantzikinakis, C. and Kiparissides, C., “A Comprehensive Experimental & Theoretical Investigation of the Styrene/2-Ethylhexyl Acrylate Emulsion Copolymerization”, Macromolecular Chem & Phys, 204, 983-999 (2003)
- Kotoulas, C., Krallis, A., Pladis P. and Kiparissides C., “A Comprehensive Kinetic Model for the Combined Chemical and Thermal Polymerization of Styrene up to High Conversion”, Macromolecular Chemistry and Physics, 204, 1305-1314 (2003)
- Dini, E., Alexandridou, S., and Kiparissides, C., “Synthesis and Characterization of Crosslinked Chitosan Microspheres for Drug Delivery Applications”, J. Microencapsulation, 20(3), 375-385 (2003)
- Tzika, M., Alexandridou, S., and Kiparissides C., “Evaluation of the Morphological and Release Characteristics of Coated Fertilizer Granules Produced in a Wurster Fluidized-Bed”, Powder Techn, 132, 16-24, (2003)
- Keramopoulos, A. and Kiparissides, C., “Mathematical Modeling of Diffusion-Controlled Free-Radical Terpolymerization Reactions”,J. of Appl. Pol. Sci. 88, 161-176 (2003)
- Chatzidoukas, C., Pladis, P. and Kiparissides, C., “Mathematical Modeling of Dispersion Polymerization of Methyl Methacrylate in Supercritical Carbon Dioxide”, Ind. & Eng. Chem Res., 42, 743-751 (2003)
- Kiparissides, C., Dimos, V., Boultouka, T., Anastasiadis, A. and Chasiotis, A., “An Experimental and Theoretical Investigation of Solubility and Diffusion of Ethylene in Semi-crystalline PE at Elevated Pressure and Temperature”, J. of Appl. Pol. Sci. 87, 953-966 (2003)
- Kiparissides, C., Seferlis, P., Mourikas, G and Morris, A.J., “On-line Optimizing Control of Molecular Weight Properties in Batch Free Radical Polymerization Reactors”, Ind. & Eng. Chem Res. 41(24), 6120-6131 (2002)
- Kiparissides, C., Achilias, D.S., and Frantzikinakis, C., “The Effect of Oxygen on the Kinetics and Particle Size Distribution in Vinyl Chloride Emulsion Polymerization”, Ind. & Eng. Chem Res. 41(13), 3097-3109 (2002)
- Keramopoulos, A. and Kiparissides, C., “Development of a Comprehensive Model for Diffusion-Controlled Free-Radical Copolymerization Reactions”, Macromolecules, 35 (10), 4155-4166 (2002)
- Alexopoulos, A.H., Maggioris, D. and Kiparissides, C., “CFD Analysis of Turbulence Non-Homogeneity in Mixing Vessels a Two-compartment Model”, Chem Eng Sci, 57(10), 1735-1752 (2002)
- E.A. Efthimiadis, A.A. Lappas, D.K. Iatrides and I.A. Vasalos, “Selective Catalytic Reduction of NOx by Hydrocarbons/Oxygenates. Application for the Control of NOx from the Regenerator of an FCC Pilot Plant Unit”, Ind. Eng. Res. Dev, 40, 2001.
- A.A. Lemonidou, L. Nalbandian, I.A. Vasalos, “Oxidative Dehydrogenation of Propane over Vanadium Oxide Based Catalysts. Effect of Support and Alkali Promoter”, Catal. Today, 61 333, (2000).
- Tzevelekos K.P., Kikkinides E.S., Kainourgiakis M.E., Stubos A.K., Kanellopoulos N.K. and Kaselouri V., “Adsorption-Desorption Condensable Vapor Permeability through Mesoporous Media. Network Modeling and Percolation Theory”, J. Colloid Interf. Sci., 223, 89 (2000).
- Kikkinides E.S., Kainourgiakis M.E., Stefanopoulos K., Mitropoulos A.Ch., Stubos A.K. and Kanellopoulos N.K., “0Combination of Small Angle Scattering and 3-D Stochastic Reconstruction for the Study of Adsorption-Desorption Processes in Vycor Porous Glass”, J. Chem. Phys., 112(22), 9881 (2000).
- G.Ch. Charalambopoulou, P. Karamertzanis, E.S. Kikkinides, A.K. Stubos, N.K. Kanellopoulos, A.Th. Papaioannou, “A Study on Structural and Diffusion Properties of Porcine Stratum Corneum based on Very Small Angle Neutron Scattering Data”, Pharmaceutical Research, 17(9) 1085 (2000).
- Zouridakis N., Economou I., Tzevelekos K.P. and Kikkinides E.S., ”Investigation of the Physicochemical Characteristics of Ancient Mortars by Static and Dynamic Studies”, Cement and Concrete Research, 30(7), 1151 (2000).
- Kikkinides E.S. and Burganos V.N., “Permeation properties of three-dimensional self-affine reconstructions of porous materials”, Physical Review E, 62(5) 6906 (2000).
- M.E. Kainourgiakis, E.S. Kikkinides, Th.A. Steriotis, A.K. Stubos, K.P. Tzevelekos, and N.K. Kanellopoulos, “Structural and Transport Properties of Alumina Porous Membranes from Process-Based and Statistical Reconstruction Techniques”, J. Colloid Interf. Sci., 231,157 (2000).
- Kikkinides E.S., Steriotis Th., Stubos A.K., Stefanopoulos K., Mitropoulos N. and Kanellopoulos N.K., “Structural Characterization and Applications of Ceramic Membranes for Gas Separations”, STUD SURF SCI CATAL, Vol. 128, 429-438 (2000).
- Kallus S., Langlois P., Romanos G.E., Steriotis Th., Kikkinides E.S., Kanellopoulos N.K. and Ramsay J.D.F., “Zeolite Membranes - Characterisation and Application in Gas Separations”, STUD SURF SCI CATAL, Vol. 128, 467-474 (2000).
- Charalambopoulou G.Ch., Kikkinides E.S., Stubos A.K., Varelas C.G. and Papaioannou A., “Modeling Sustained Drug Release from Biphasic Polymer Hydrogels” , J. Contr. Rel., 64, 338 (A) (2000).
- K.Eleftheriadis, A.Angelaki, A.Kungolos, L. Nalbandian, G.P.Sakellaropoulos, “Assessing the Impact of Atmospheric Wet and Dry Deposition using Chemical and Toxicological Analysis”, in G.Persoone (ed.) “New Microbiotests for Routine Toxicity Screening and Biomonitoring”, Kluver Academic/Plenum Publishers, New York, 2000, pp.469-473.
- Samolada M. C., Papafotica A. and I. A. Vasalos, “Catalyst evaluation for catalytic biomass pyrolysis for the production of improved quality bio-oil”, Energy & Fuels, 2000, 14, 1161-1167.
- Toubeli A.; Efthimiadis, E.A.; Vasalos I.A., "NO reduction by C3H6 in excess oxygen over fresh and sulfated Pt- and Rh-based catalysts", Catal. Lett., 2000, 69, 157.
- Christoforou, S.C.; E.F. Iliopoulou; Efthimiadis, E.A.; A.A. Nikolopoulos; Vasalos, I.A., "Novel bifunctional catalytic systems for the SCR of NOx using hydrocarbons using reductants: Step one, NO oxidation", Global Nest: the Int. J., 2000, 2, 159.
- Sanopoulos D., Kunglos A. Keramaris V., Kiparissidi Z., "Developing a database for energy and environment: Ôhe Hephaistos project", Fresenius Environmental Bulletin (FEB), 2000, Vol. 9, n. 5-6, p. 281-286.
- Kikkinides E.S., Kainourgiakis M.E. and Kanellopoulos N.K., “Simulation of Gas Transport in a Network of Micropores. The effect of pore structure on Transport Properties”, in Membrane Science and Technology Series 6, N. Kanellopoulos ed., Elsevier, Chapter 2.3 p.297-322 (2000).
- Georgiadis, M.C., and Macchietto S. (2000) “Dynamic Modelling and Simulation of Plate Heat Exchangers under Milk Fouling”, Chemical Engineering Science, 55, 1605-1619.
- Georgiadis, M.C., Papageorgiou, L.G., and Macchietto S., (2000), “Optimal Cleaning Policies in Heat Exchanger Networks under rapid fouling”, Ind. Eng. Chem. Res., 39 441-454.
- Georgiadis, M.C. and L.G. Papageorgiou (2000), "Optimal Cleaning and Energy Management in Heat Exchanger Networks under Fouling", Chem. Eng. Res. & Des., 78 Part A, 168-179.
- Stavropoulos Y. and Kiparissides, C: “Development of a software package for quality assurance and statistical process control”, Tech. Chron. Science Journal, TCG, V 21 (1-2) : 7-17 (2001)
- Stavropoulos, Y. and Kiparissides, C., “Development of a Prototype MSPC Software Package for On-line Process Monitoring and Statistical Quality Control”, Comp. Appl. in Eng. Edu., 9, 157-170, (2001)
- Stavropoulos, Y., Kammona, O., Chatzi, E.G. and Kiparissides, C., “Multivariate Statistical Analysis of Mid-Infrared Spectra for the On-line Monitoring of 2-Ethylhexyl Acrylate/Styrene Emulsion Copolymerization”, J. of Appl. Pol. Sci., 82, 1776-1787 (2001)
- Yiagopoulos, Α., Yiannoulakis, H., Dimos, V. and Kiparissides, C., “Heat and Mass Transfer Phenomena during the Early Growth of a Catalyst Particle in Gas Phase Olefin Polymerizations: The Effect of Prepolymerization Temperature and Time”, Chem. Eng Sci, 56, 3979-3995 (2001)
- Alexandridou, S., Kiparissides, C., Mange, F. and Foissy, A., “Surface Characterization of Oil-containing Polyterephtalamide microcapsules prepared by Interfacial Polymerization”, J. Microencapsulation, 18, No 6, 767-781 (2001)
- Lazaridis, N., Alexopoulos, A. and Kiparissides, C., “Semi-Batch Emulsion Copolymerization of Vinyl Acetate and Butyl Acrylate Using Oligomeric Nonionic Surfantants”, Macromol. Chem. Phys., 202, 2614-2622 (2001)
- Mourikas, G.; Seferlis, P.; Morris, A. J.; Kiparissides, C., “On-line Optimal Operating Policy and Control of a Batch Free Radical Polymerization Process”, Computer Aided Chemical Engineering, 9, 705-710, (2001)
- Yiagopoulos, H. Yiannoulakis, J. Morris and Kiparissides, C. “Simulation of an Industrial Olefin Polymerization FBR Operating under Condensed Mode”, Computer Aided Chemical Engineering, 9, 327-332, (2001)
- Dini, E., Alexandridou, S. and Kiparissides, C., “Synthesis and Characterization of Crosslinked Microparticles for Drug Delivery”,Chimia, 55, 239-241 (2001)
- Yiannoulakis H., Yiagopoulos, and Kiparissides, C., “Recent Developments in the Particle Size Distribution Modeling of Fluidized Bed Olefin Polymerization Reactors”, Chem. Eng. Sci., 56, 917-925 (2001)
- Maggioris, D., Goulas, A., Alexopoulos, A.H., Chatzi, E.G. and Kiparissides, C., “Prediction of Particle Size Distribution in Suspension Polymerization Reactors: Effect of Turbulence Nonhomogeneity”, Chem. Eng. Sci., 55, 4611-4627 (2000)
- Alexopoulos, A. and Kiparissides, C., “Solution of population balance equations for prediction of particle size distribution in emulsion polymerization: comparison and evaluation of different numerical methods”, Computer-Aided Chemical Engineering 8, 43-48 (2000)
- Yiannoulakis H., Yiagopoulos, A., Pladis, P. and Kiparissides, C., “Comprehensive Dynamic Model for the Calculation of the Molecular Weight and Long Chain Branching Distributions in Metallocene-Catalyzed Ethylene Polymerization Reactors”, Macromolecules, 33 (7), 2757-2766 (2000)
- Hatzantonis, H., Yiannoulakis H., Yiagopoulos, A. and Kiparissides, C., “Recent Developments in Modeling Gas-Phase Catalyzed Olefin Polymerization Fluidized Bed Reactors: The Effect of Bubble Size Variation on the Reactor’s Performance”, Chem.Eng.Sci., 55, 3237-3259 (2000)
- Martin, E.B., Morris, A.J. and Kiparissides, C., “Manufacturing Performance Enhancement Through Multivariate Statistical Process Control”, Annual Reviews in Control, 23, 35-44 (1999)
- Lazarides, N., Alexopoulos, A., Chatzi, E.G. and Kiparissides, C., "Steric Stabilization in Emulsion Polymerization Using Oligomeric Nonionic Surfactants", Chem. Eng. Sci., 54, 3251-3261 (1999)
- Pladis, P., and Kiparissides, C., “Dynamic Modeling of Multizone, Multifeed High Pressure LDPE Autoclaves”, Journal of Applied Polymer Science, 73, 2327-2348 (1999)
- Zhang, J., Martin, E.B., Morris, A.J. and Kiparissides, C., “Estimation of Impurity and Fouling in Batch Polymerization Reactors through the Application of Neural Networks”, Computer &. Chemical Engineering, 23, 301-314 (1999)
- Kammona, O. Chatzi, E.G., and Kiparissides, C., “Recent Developments in Hardware Sensors for the On-line Monitoring of Polymerization Reactions”, Journal of Macromolecular Science, Reviews in Macromolecular Chemistry and Physics, C39(1), 57-134 (1999)
- Pladis, P., and Kiparissides, C., “Calculation of Long-Chain Branching and Molecular Weight Distribution in LDPE Reactors. A Comprehensive Model”, Entropie, 212/213, 37-44 (1998)
- Chatzi, E.G., Nasiopoulos, V. and Kiparissides C. “Stabilization of Liquid (Solid)/ Liquid Dispersions in Polymerization Reactors”, Entropie, 212/213, 75-80 (1998)
- Maggioris, D., Goulas, A., Alexopoulos, A.H., Chatzi, E.G. and Kiparissides C., “Prediction of Drop Size Distributions in Suspension Polymerization Reactors: Effects of Agitation Rate, Viscosity and Interfacial Tension”, DECHEMA, Berlin, Germany, October 5-7 (1998)
- Kammona, O., Chatzi, E.G. and Kiparissides C., “On-Line Monitoring of Emulsion Copolymerization Using a MIR Probe in Combination with Factor Analysis”, DECHEMA, Berlin, Germany, October 5-7 (1998)
- Maggioris, D., Goulas, A., Alexopoulos, A.H., Chatzi, E.G., and Kiparissides, C., “Use of CFD in Prediction of Particle Size Distribution in Suspension Polymer Reactors”, Computers and Chemical Engineering, 22, Suppl., S315-322 (1998)
- Hatzantonis, H. and Kiparissides, C., “The Effect of the Mean Particle Size on the Dynamic Behaviour of Catalyzed Olefin Polymerization Fluidized Bed Reactors”, Computers and Chemical Engineering, 22, Suppl., S127-134 (1998)
- Baltsas, A., Papadopoulos, E. and Kiparissides, C., “Application and Validation of the Pseudo-Kinetic Rate Constant Method to High Pressure LDPE Tubular Reactors”, Computers and Chemical Engineering, 22, Suppl., S95-102 (1998)
- Toubeli, A. and Kiparissides, C., “Synthesis and Characterization of Polyterephthalamide Membranes for Encapsulation Use: Effect of the Amine Type and Composition on the Membrane Permeability”, Journal of Membrane Science, 146, 15-29 (1998)
- Hatzantonis, H., Goulas, A. and Kiparissides, C., “A Comprehensive Model for the Prediction of Particle Size Distribution in Catalyzed Olefin Polymerization Fluidized Bed Reactors”, Chemical Engineering Science, 53, 3251-3267 (1998)
- Zhang, J., Morris, A.J., Martin, E.B. Martin and Kiparissides, C., “Prediction of Polymer Quality in Batch Polymerization Reactors Using Robust Neural Networks”, Chem. Eng. J., 69, 135-143 (1998)
- Pladis, P. and Kiparissides, C., “A Comprehensive Model for the Calculation of Molecular Weight-Long Chain Branching Distribution in Free-Radical Polymerization”, Chemical Engineering Science, 53, 3315-3333 (1998)
- Liakopoulou-Kyriakides, M., Tzanakakis, E.S., Kiparissides C., Ekaterianiadou, L.V., Kyriakidis, D.A., “Kinetics of Xanthan Gum Production from Whey by Constructed Strains of Xanthomonas Campestris in Batch Fermentations”, Chemical & Engineering Technology, 20(5), 354-360 (1997)
- Chatzi, E.G., Kammona, O, Kentepozidou and Kiparissides, C., “Infrared Spectra and Compositional Analysis of Styrene/2-Ethyl Hexyl Acrylate Copolymers”, Macromolecular Chemistry and Physics, 198, 2409-2420 (1997)
- Boutris, C., Chatzi, E. and Kiparissides, C., “Characterization of the LCST Behaviour of Aqueous Poly(N-Isopropylacrylamide) Solutions by Thermal and Cloud Point Techniques”, Polymer, 38(10), 2567-2570 (1997)
- Kiparissides, C., Daskalakis, G., Achilias, D.S., and Sidiropoulou, E., “Dynamic Simulation of Industrial PVC Batch Suspension Polymerization Reactors”, I&EC Research, 36(4), 1253-1267 (1997)
- Zhang, J., Martin, E.B., Morris, A.J. and Kiparissides, C., “Inferential Estimation of Polymer Quality Using Stacked Neural Networks”, Computers and Chemical Engineering, 21, Suppl., S1025-1030 (1997)
- Chatzi, E.G., Kammona, O. and Kiparissides, C., “Use of a Mid-Range Infrared Optical-Fiber Probe for the On-line Monitoring of 2-Ethyl Hexyl Acrylate/ Styrene Emulsion Copolymerization”, Journal of Applied Polymer Science, 63, 799-809 (1996)
- Bachtsi, A.R. and Kiparissides, C., “Synthesis and Release Studies of Oil-Containing Poly(Vinyl Alcohol) Microcapsules Prepared by Coacervation”, Journal of Controlled Release, 38(1), 49-58 (1996)
- Kentepozidou, A., Kiparissides, C., Kotzia, C., Kollia, C. and Spyrellis, N., “Nickel/Microcapsules Composite Electrocoatings. Synthesis of Water-Containing Microcapsules and Preparation of the Coatings”, Journal of Materials Science, 31, 1175-1181 (1996)
- Bachtsi, A., Boutris, C. and Kiparissides, C., “Production of Oil-Containing Cross-linked Poly(vinyl Alcohol) Microcapsules by Phase Separation: Effect of Process Parameters on the Capsule Size Distribution”, Journal of Applied Polymer Science, 60, 9-20 (1996)
- Pertsinides, A., Papadopoulos, E. and Kiparissides, C., “Computer Aided Design of Polymer Reactors”, Computers & Chemical Engineering, 20, Suppl. A., S449- S455 (1996)
- Kiparissides, C. and Morris, J., “Intelligent Manufacturing of Polymers”, Computers & Chemical Engineering, 20, Suppl. B., S1113- S1118 (1996)
- Martin, E.B., Morris, J., Papazoglou, M.C. and Kiparissides, C., “Batch Process Monitoring for Consistent Production”, Computers & Chemical Engineering, 20, Suppl. B., S599- S605 (1996)
- Kiparissides, C., Verros, G., Pertsinides, A. and Goossens, I., “On-Line Parameter Estimation in High-Pressure LDPE Tubular Reactor”, A.I.Ch.E. J., 42, 440-454 (1996)
- Kiparissides, C., “Polymerization Reactor Modelling: A Review of Recent Developments and Future Directions”, Chemical Engineering Science, 51(10), 1637-1659 (1996)
- Topalis, E., Pladis, P. and Kiparissides, C., “Dynamic Modeling and Steady-State Multiplicity in HighPressureMultizone LDPE Autoclaves”, Chemical Engineering Science, 51(10), 2461-2470 (1996)
- Baltsas, A., Achilias, D. and Kiparissides, C., “A Theoretical Investigation of the Production of Branched Copolymers in Continuous Stirred Tank Reactors”, Macromolecular Theory and Simulation, 5, 477-497 (1996)
- Kentepozidou, A. and Kiparissides, C., “Production of Water-Containing Polymer Microcapsules by the Complex Emulsion/Solvent Evaporation Technique. Effect of Process Variables on the Microcapsule Size Distribution”, Journal of Microencapsulation, 12, 627-638 (1995)
- Bachtsi, A. and Kiparissides, C., “An Experimental Investigation of Enzyme Release from Poly(vinyl alcohol) Crosslinked Microspheres”, Journal of Microencapsulation, 12(1), 23-35 (1995)
- Alexandridou, S., Kiparissides, C., Fransaer, J., and Celis, J.P. “On the Synthesis of Oil-Containing Microcapsules and their Electrolytic Codeposition”, Surface and Coatings Technology, 71, 267-276 (1995)
- Chatzi, E. and Kiparissides, C., “Steady-State Drop Size Distribution in High Holdup Fraction Dispersion Systems”, A.I.Ch.E. J., 41, 1640-1652 (1995)
- Topalis, E., Pladis, P. and Kiparissides, C., “Computer Aided Design of Multizone, Multifeed LDPE Autoclaves”, 5thInternational Workshop on Polymer Reaction Engineering, DECHEMA, Reichert, K.-H., and Moritz, H.-U., (eds), Vol. 131, 631-653 (1995)
- Kiparissides, C., Papadopoulos, E. and Morris, J., “Real-Time Optimization and Model-Based Control of Polymer Reactors”, NATO-ASI on Methods of Model Based Process Control, Ed. Berber, R., Martnus Nijhoff Publishers, 495-530 (1995)
- Kiparissides, C., Achilias, D.S., and Chatzi, E., "Dynamic Simulation of Primary Particle-Size Distribution in Vinyl Chloride Polymerization", J. of Applied Polymer Sci., 54, 1423-1438 (1994)
- Chatzi, E. and Kiparissides, C., "Drop Size Distribution in High Holdup Fraction Suspension Polymerization Reactors: Effect of the Degree of Hydrolysis of PVA Stabilizer", Chem. Eng. Sci., 49(24) , 5039-5052 (1994)
- Kiparissides, C., Verros, G. and Pertsinides, A., "On-line Optimization of a High Pressure Low Density Polyethylene Tubular Reactor", Chem. Eng. Sci., 49, 5011 (1994)
- Achilias, D. and Kiparissides, C. "On the Validity of the Steady-State Approximations in High Conversion Diffusion-Controlled Free-Radical Copolymerization Reactions", Polymer, 35, 1714-1721 (1994)
- J.F. MacGregor, Jaeckle, C., Kiparissides, C. and Koutoudi, M., "Process Monitoring and Diagnosis by Multi-Block PLS Methods", A.I.Ch.E. J., 40, 826-838 (1994)
- Alexandridou, S. and Kiparissides, C., "Production of Oil-Containing Polyterephthalamide Microcapsules by Interfacial Polymerization. An Experimental Investigation of the Effect of Process Variables on the Microcapsule Size Distribution", J. of Microencapsulation, 11(6), 603-614 (1994)
- Kiparissides, C., Verros, G. and MacGregor, J. F. "Mathematical Modeling, Optimization and Quality Control of High-Pressure Ethylene Polymerization Reactors", J.M.S.- Rev. Macrom. Chem. Phys., C33(4), 437-527 (1993)
- Verros, G., Papadakis, M., and Kiparissides, C. "Mathematical Modeling of High Pressure Ethylene Copolymerization Reactors", Polym. Reaction Engin. J., 1(3), 427-460 (1993)
- Kiparissides C., Verros, G., Kalfas, G., Koutoudi, M. and Kantzia, C. and "A Comprehensive Mathematical Model of a Multizone Tubular High Pressure LDPE Reactor", Chem. Engin. Commun., 121, 193-217 (1993)
- Kiparissides, C., Moustakis, I. and Hamielec, A.E. "Electrostatic and Steric Stabilization of PVC Primary Particles", J. Appl. Polym. Sci., 44, 445-459 (1993)
- Skagerberg, B., MacGregor, J.F. and Kiparissides, C., "Multivariate Data Analysis Applied to Low-Density Polyethylene Reactors", Chemometrics and Intelligent Laboratory Systems, 14, 341-356 (1992)
- Achilias, D. and Kiparissides, C. "Development of a General Mathematical Framework for Modelling Diffusion-Controlled Free Radical Polymerization Reactions", Macromolecules, 25, 3739 (1992)
- Penlidis, A., Ponnuswammy, S.R., Kiparissides, C. and O'Driscoll, K.F., "Polymer Reaction Engineering: Modelling Considerations for Control Studies", Chemical Engin. J., 50, 95 (1992)
- Konstandinidis, K., Achilias, D. and Kiparissides, C. "Development of a Unified Mathematical Framework for Modelling Molecular and Structural Changes in Free Radical Homopolymerization Reactions", Polymer, 33, 5019 (1992)
- Achilias, D. and Kiparissides, C. "Toward the Development of a General Framework for Modeling Molecular Weight and Compositional Changes in Free Radical Copolymerization Reactions", J.M.S.- Rev. Macromol. Chem. Phys. C32, 183 (1992)
- Chatzi, E.G. and Kiparissides, C., "Dynamic Simulation of Bimodal Drop Size Distributions in Low-Coalescence Batch Dispersion Systems", Chem. Eng. Sci., 47, 445 (1992)
- Know, W.Y., Kiparissides, C., Yuet, P. Harris, T.J. and Goosen, M.F.A., "Mathematical Modelling of Diffusion Effects in Microcapsules: A Comparison With Experimental Results", Can. J. Chem. Eng., 69, 361 (1991)
- Mikos, A.G. and Kiparissides, C. "Skin Formation in Heterogeneous Polymerization Reactions", J. Membrane Science, 59, 205 (1991)
- Chatzi, E.G., Boutris, C., and Kiparissides, C. "On-line Monitoring of Drop Size Distributions in Agitated Vessels: II. Effects of Stabilizer Concentration", Ind. Eng. Chem. Res., 1307, 30 (1991)
- Chatzi, E.G., Boutris, C., and Kiparissides, C., "On-line Monitoring of Drop Size Distributions in Agitated Vessels: I.Effects of Temperature and Impeller Speed", Ind. Eng. Chem. Res., 30, 536 (1991)
- Kiparissides, C., Sidiropoulou, E., Voutetakis, S. and Frousakis, C., "Control of Molecular Weight in a Batch Polymerization Reactor Using Long-Range Predictive Control Methods", Commun. in Chem. Engin., 92, 1 (1990)
- Sidiropoulou, E. and Kiparissides, C., "Mathematical Modelling of PVC Suspension Polymerization: A Unifying Approach and Some New Results", J. Macromol. Sci. Chem. A27(3), 257 (1990)
- Kiparissides, C. "Prediction of the Primary Particle Size Distribution in Vinyl Chloride Polymerization", Die Makromol. Chemie, Macrom. Symp. 35/36, 171 (1990)
- Diamadopoulos, E., Zoubourtikoudis, I. and Kiparissides, C., "Aggregation Phenomena in the Suspension Polymerization of VCM", Colloid and Polym. Sci. J., 286, 306 (1990)
- Chatzi, E.G., Gavrielides, A. and Kiparissides, C., "Generalized Model for Prediction of the Steady-State Drop Size Distributions in Batch Stirred Vessels" Ind.Eng. Chem. Res., 28, 1704 (1989)
- Ponnuswamy, S.R., Kiparissides, C., Penlidis, A. and O'Driscoll, K.F., "Batch Solution Polymerization of Methyl Methacrylate: Parameter Estimation", Chemical Engineering Journal, 39, 175 (1989)
- Achilias, D. and Kiparissides, C. "Modelling of Diffusion-Controlled Free-Radical Polymerization Reactions", J. Appl. Polym. Sci., 35, 1303 (1988)
- Achilias, D. and Kiparissides, C., "Mathematical Modelling of Thermal Co-polymerization of Styrene/p-Methylstyrene", Polymer Process Engin., 5, 23 (1987)
- Kiparissides, C. and Georgiou, A., "Finite Element Solution of Nonlinear Optimal Control Problems with a Quadratic Performance Index", Comput. Chem. Eng., 11, 77 (1987)
- Ponnuswamy, S.R., Shah, S.L. and Kiparissides, C., "Computer Optimal Control of Batch Polymerization Reactors", I & EC Process Design and Development, 26, 2229 (1987)
- Ponnuswamy, S.R., Shah, S.L. and Kiparissides, C., "On-line Monitoring of MWD in a Batch Polymerization Reactor by Size Exclusion Chromatography", J. Liquid Chrom., 9, pp. 2411-2423 (1986)
- Kiparissides, C. and Mavridis, H., "Mathematical Modelling and Sensitivity Analysis of High Pressure Polyethylene Reactors" ; Chemical Reactor Design and Technology, H. De Lasa ed., Martinus Nijhoff Publishers, Dordrecht, pp. 759-777 (1986)
- Ponnuswamy, S.R., Shah, S.L. and Kiparissides, C., "On-line Monitoring of Polymer Quality in a Batch Polymerization Reactor", J. Appl. Polym. Sci., 32, pp. 3239-3253 (1986)
- Mavridis, H. and Kiparissides, C., "Optimization of a High Pressure Polyethylene Tubular Reactor", Polym. Proc. Eng., 3, pp. 263-290 (1985)
- Thomas, I.M. and Kiparissides, C., "Computation of the Near-Optimal Temperature and Initiator Policies for a Batch Polymerization Reactor", Can. J. Chem. Eng., m 62, pp. 284-291 (1984)
- Thomas, I.M. and Kiparissides, C., "Sensitivity Analysis of a Batch Polymerization Reactor", J. Appl. Polym. Sci., 29, pp. 2195-2204 (1984)
- Kiparissides, C. and Shah, S.L., "Self-Tuning and Stable Adaptive Control of a Batch Polymerization Reactor", Automatica, 19, pp. 225-235 (1983)
- Kiparissides, C. and Ponnuswamy, S.R., "Application of Population Balance Equations to Latex Reactors", Chem. Eng. Commun., 10, pp. 283-291 (1981)
- Lynch, D. and Kiparissides, C., "Numerical Simulation of a Tubular Polymerization Reactor", J. Appl. Polym. Sci., 26, pp. 1283-1293 (1981)
- Kiparissides, C., MacGregor, J.F. and Hamielec, A.E., "Suboptimal Stochastic Control of a Continuous Latex Reactor", AIChE Journal, 27, pp. 13-19 (1981)
- Kiparissides, C. and Ponnuswamy, S.R., "Hierarchical Control of a Train of Continuous Polymerization Reactors", Can. J. Chem. Eng., 59, pp. 752-759 (1981)
- Kiparissides, C., MacGregor, J.F. and Hamielec, A.E., "Characterization of Size Distribution during Continuous Emulsion Polymerization - Oscillations in Vinyl Acetate Polymerization", in Polymer Colloids II, ACS-Symposium Series, Plenum Publishing Co., N.Y., pp. 555-582 (1980)
- Kiparissides, C., MacGregor, J.F., Singh, S. and Hamielec, A.E., "Continuous Emulsion Polymerization of Vinyl Acetate. Part III: Detection of Reactor Performance by Turbidity - Spectra and Liquid Exclusion Chromatography", Can. J. Chem. Eng., 58, pp. 65-71 (1980)
- Kiparissides, C., MacGregor, J.F. and Hamielec, A.E., "Continuous Emulsion Polymerization of Vinyl Acetate. Part II: Parameter Estimation and Simulation Studies", Can. J. Chem. Eng., 58, pp. 56-64 (1980)
- Kiparissides, C., MacGregor, J.F. and Hamielec, A.E., "Continuous Emulsion Polymerization of Vinyl Acetate. Part I: Experimental Studies", Can. J. Chem. Eng., 58, pp. 48-55 (1980)
- Kiparissides, C., MacGregor, J.F. and Hamielec, A.E., "Continuous Emulsion Polymerization. Modelling Oscillations in Vinyl Acetate Polymerization", J. Appl. Polym. sSci., 23, pp. 401-418 (1979)
- Kiparissides, C. and Vlachopoulos, J., "A Study of Viscous Dissipation in the Calendering of Power-Law Fluids", Poly. Eng. Sci., 18, pp. 210-214 (1978)
- Kiparissides, C. and Vlachopoulos, J., "Finite Element Analysis of Calendering", Poly. Eng. Sci., 16, pp. 712-719 (1976)
Doctoral Dissertations and Diploma Thesis
- Vassiliadou Athena
- Karageorgos Filippos
- Bakola Veroniki
- Tsanaktsidou Jenny
- Rezaei, M., “Mathematical Modeling of Micro-, Meso- and Macro-Scale Phenomena on a Heterophase Catalytic Reactor”
- Athanasiou, E.V., “Controlled Antigen Delivery Systems Cell Targeting and Functional Differentiation”, (2015).
- Samaridou, E. “Development of Nanocarriers for Oral and Ocular Administration of Biopharmaceutics”, (2015).
- Bourganis, V. “Nanocarriers with Tunable Mucus Penetration and Release Properties for Controlled Delivery of Biomolecules”, (2015).
- Karamanidou, Th., “Mucus Permeating Nanocarriers for Controlled Drug Delivery”, (2015).
- Kontonikola, A., “Synthesis of Polymeric Nanocarriers for the Targeted Delivery of Antigens to Dendritic Cells”, (2015).
- Milenkovic, J., “Simulation of Flow and Particle Deposition in a Dry Powder Inhaler”, (2015).
- Koroneou, M., “Synthesis of Advanced Hybrid Core-Shell Nanoparticles for the Surface Protection and Sealing”, (2015).
- Karapatsia, A., “Experimental Study of Biofuels and High Value-added Biochemicals Production from Lignocellulosic Biomass”, (2015).
- Gementzoglou, Ch., “Synthesis of Hybrid Membranes for the Removal of Organic Pollutants from Water”, (2014).
- Seretis, A., “Dynamic Behavior and Optimization of Multi-Phase Catalytic Slurry Loop Reactors for the Production of Polyolefins”, (2011).
- Mantourlias, Th., “Immobilization of enzymes in polymeric matrices, microcapsules and ceramic monoliths and their application in biopolymers production”, (2011).
- Kretza, E., “Development οf Microencapsulation Techniques with Applications in Chemical Technology and Biotechnology”, (2011).
- Karakosta, P., “Controlled Release Systems for Pulmonary Delivery of Proteins/Peptides”, (2011).
- Touloupides, V., “Mathematical Modelling and Simulation of an Industrial a-Olefins Catalytic Slurry Phase Loop-Reactor Series”, (2010).
- Penloglou, J., “Study fo the microbial production of polyhydroxyalkanoates (PHAs) in a bioreactor. Mathematical modeling and process optimization”, (2010).
- Boukhari, M., “Synthesis of Nanoparticles by Mini-emulsion Polymerization”, (2009).
- Saliakas, V., “Non-Linear Mathematical Model Based Control of Polymerization Reactors”, (2008).
- Meimaroglou, D., “Stochastic Dynamic Simulation and Solution of Multidimentional Population Balance Equations with Application to Polymerization Processes”, (2008).
- Kotti, A., “Synthesis and Applications of Hybrid Nanocomposites”, (2008).
- Kotrotsiou, O., “Study of Molecularly Imprinted Polymers for Analytical Applications”, (2008).
- Chaitidou, S., “Hybrid Materials: Biomolecule-polymer Conjugates for Drug Delivery and Biosensor Applications”, (2008).
- Dompazis, G., “Dynamic Simulation of Olefin Polymerization Fluidized Bed Reactors: Prediction of the Particle Size Distribution of Polymeric Particles”, (2007).
- Krallis, A., “Dynamic Simulation and Non-Linear Optimization of Industrial Polymerization Processes”, (2007).
- Kotoulas, C., “Prediction of Particle Size Distribution in Suspension Polymerization Reactors”, (2006).
- Kanellopoulos, V., “An Experimental and Theoretical Investigation on the Morphological Properties of Polymer Particles during the Heterogeneous Gas Phase Catalytic Olefin Polymerization”, (2006).
- Roussos, A., “Development of Numerical Methods for the Solution of the Population Balance Equation-Application to Emulsion Polymerization Reactors”, (2004).
- Parouti, S., “Investigation of the Kinetics and the Molecular weight Distribution in Semi-Batch Emulsion Polymerization Reactors”, (2004).
- Dini, E., “Molecular and Nano-Scale Drug Delivery Systems”, (2004).
- Kehagia, Z., “Determination and Removal of Monomers and Volatile Compounds from Polymers Produced by Emulsion Polymerization”, (2004).
- Chatzidoukas, C., “Polymerization Reactor Modeling, Design, Optimization and Control”, (2004) (in collaboration with the Imperial College, Britain).
- Tzika, Μ. “Experimental Investigation of the Production of Controlled Release Fertilizers Using Physical and Chemical Encapsulation Methods”, (2001).
- Stavropoulos, J., “Multivariate Statistical Control of the Chemical Processes”, (2001).
- Lazaridis, Ν., “New Generation Surfactants for the Latex Polymerization Process and High Quality Environmentally Friendly Coatings”, (2001).
- Keramopoulos, A., “Mathematical Modeling of Polymerization Reaction Kinetics and Phase Equilibria at High Conversions”, (2001).
- Giannoulakis, H., “Study of Gas Phase Olefin Polymerization Using Metallocene Catalysts”, (2001).
- Giagopoulos, Α., “Mathematical Modeling of Olefin Plastomer and Elastomer Polymerization Reactors Using Heterogeneous Catalysts”, (2001).
- Fratzikinakis, C., “Modeling and Trajectory Control of Semi-Batch Emulsion Copolymerization”, (2001).
- Dimos, V., “Experimental and Theoretical Investigation of Heterogeneously Catalyzed Olefin Gas and Liquid Phase Polymerization”, (2001).
- Pladis, P., “Dynamic Behaviour, Steady-State Multiplicity and Non-Linear Control of High Pressure Tubular and Vessel LDPE Reactors”, (2000).
- Toubeli, Α., “Synthesis and Characterization of Hydrophilic Polymeric Membranes for Controlled Release Applications”, (1999).
- Hatzantonis, H., “Mathematical Simulation of Polymeric Particle Behaviour in a Fluidized Bed Reactor”, (1999) (in collaboration with Mechanical Engineering Department).
- Kammona, Ο., “Synthesis of Polymeric Nanoparticles and Development of Analytical Techniques for the Determination of their Molecular and Morphological Properties”, (1999).
- Papazoglou, Μ., “Multivariate Statistical Process Control (SPC) of Batch Polymerization Reactors”, (1998) (in collaboration with the University of Newcastle, Britain).
- Mourikas, G., “Mathematical Modeling, and Optimization of Batch Polymerization Reactors”, (1998) (in collaboration with the University of Newcastle, Britain).
- Sidiropoulou, Ε., “Mathematical Modeling and Optimization of a VCM Suspension Polymerization Reactor”, (1997).
- Boutris, C., “An Experimental and Theoretical Analysis of the Thermodynamic Behaviour of Water-Soluble Polymers and Gels”, (1997).
- Bachtsi, Α., “Development of Novel Microencapsulation Methods for Controlled Release Applications”, (1997).
- Verros, G., “Modeling and Real-Time Optimization of a Batch Suspension Polymerization Reactor “, (1994).
- Voutetakis, S., “Computer Aided Operation and Control of a Batch Suspension Polymerization Reactor”, (1992).
- Achilias, D., “An Experimental and Theoretical Investigation of Diffusion-Controlled Free-Radical Copolymerization Reactions”, (1991).
In Progress or Completed
- Georgiou, A. (1982) “Application of the Finite Element Method to the Solution of Time Optimal Control Problems with Initial and Final Boundary Conditions”
- Tzouanas, B., (1982) Self-tuning Adaptive Control of a Batch PVC Reactor
- Anastasiades, S. – Mikos, A. (1983) “Sensitivity Analysis of a High-Pressure Polyethylene Tubular Reactor
- Theodoulides, S. – Taurides, E. (1983) “Application of Non-linear Programming to the Optimization of Chemical Engineering Processes“
- Petroulakis, G.E. (1983) “Optimization of a Series of Continuous Stirred Tank Styrene Polymerization Reactors
- Sarris, M. – Tzoganakis, K. (1983) “Investigation of the Dynamic Performance of a Trickle-bed Reactor
- Valtaras. S. – Mavrides , Ch. (1984) “Sensitivity Analysis and Optimization of a Tubular Low-density Polyethylene Reactor”
- Karagiannis, A. (1984) “Process Analysis and Control of Distillation Columns
- Mouratides, P. (1984) “Simulation of a Series of Continuous Stirred Tank Ethylene Polymerization Reactors
- Achilias, D. (1985) “Mathematical Modeling of Free-Radical Copolymerization Reactors
- Tsakiroglou, Ch.(1985) “An Investigation of the Control of Batch Polymerization Reactors
- Giamalidou, Ek. (1986) “Mathematical Modeling of Particle Morphology in Vinyl Chloride Suspension Polymerization Reactors
- Dimitriades, B. – Papamargaritis, C. (1986) “Development of a Simulation Package for the Analysis and Design of Process Control Systems“
- Sahinides, N. (1986) “Dynamic Matrix Control (Theory and Applications)/Development of a DMC Software Package
- Azas, E. (1987) “An Investigation of the Breakage and Coalescence Phenomena in Styrene Stirred Tank Reactors
- Gavrielides, A. (1987) “An Investigation of the Breakage and Coalescence Mechanisms in Styrene/Water Dispersions
- Zoubourdikoudis, I.(1987) “An Investigation of the Primary Particle Formation in a Polymerizing VCM Droplet
- Kalfas, G. (1987) “Mathematical Simulation of a High-Pressure Tubular Polyethylene Reactor
- Constantinides, C. (1987) “A Comparative Study of Free-Radical Polymerization Modeling Methods“
- Lazarides, Th. (1987) “Mathematical Modeling and Optimization of Bioreactors
- Mertzimekis, Ch.(1987) “Installation, Modeling and Design of a Batch Reactor Control System
- Daoutides, P. (1987) “On-line Identification Methods and their Application to Adaptive Control“
- Prokopiou, Th. (1987) “Development of an On-line Technique for the Measurement of Interfacial Tension
- Saviolakis, A. (1987) “Determination of Polymer Average Molecular Weights and Molecular Weight Distributions by Gel Permeation Chromatography
- Frouzakis, Ch.(1987) “Application of Dynamic Matrix Control to Polymer Reactors
- Charitonides, P. (1987) “Simulation of a Continuous Stirred Reactor for the Production of Low-Density Polyethylene
- Daskalakis, G. (1990) “Mathematical Simulation of Batch PVC Reactors
- Koutoudi, M. – Kantzia, Ch.(1990) “Prediction of Polyethylene Molecular Properties in a Tubular High Pressure Reactor
- Banti, M. (1990) “Mathematical Modeling of a UNIPOL Polyethylene Reactor
- Bachtsi, A. – Papadopoulos, O. (1990) “Investigation of the Dynamic Particle Size Distribution in a Suspension Polymerization Reactor
- Boutris, C. (1990) “Investigation of the Dynamic Droplet Size Distribution of a Styrene/Water System in a Batch Stirred Vessel
- Nomikos, P. – Seferlis, P. (1990) “Mathematical Modeling of the Internal Morphology and Diffusion in Porous Polymeric Media
- Papadakis, M. (1990) “Ethylene Copolymerization in High Pressure Tubular Reactors
- Papadopoulos, H. (1990) “Stripping of VCM from PVC Particles
- Andreadis, S. – Polios, I.(1991) “Production and Characterization of PGA Microparticles
- Ziogas, B. (1991) “Investigation of Microencapsulation Methods for Inclusion of Organic and Biological Molecules
- Kentepozidou, A. – Macheridou, G. (1991) “An Experimental Investigation of the Porosity of PVC Particles
- Moustakis, I.(1991) “Determination of Internal Morphology of PVC Microparticles
- Alexandridou, S. (1992) “Production of Oil-containing Polyamide Nylon 6-10 Microcapsules by Interfacial Polymerization
- Dimitriades, B. – Faitakis, I.(1992) “Particle Characterization and Swelling Studies of Crosslinked Polymers by Image Processing Techniques“
- Eliopoulos, H. (1992) “Development of a Theoretical Diffusion Model for Transport of small Molecules through Polymer Membranes
- Kirides, P. Tsachourides, B. (1992) “Mixing and Stability Phenomena in Polyethylene Continuous Stirred Tank Reactors
- Makrigiannakis, G. (1992) “An Introduction to Neural Network Systems and Application to an LDPE Polymerization Reactor
- Dailianis, N. (1992) “A Molecular Thermodynamic Aproach to the Swelling Behavior of Hydrogels
- Papadopoulos, E. (1992) “Dynamic Matrix Control of a Continuous Copolymerization Reactor
- Tsolakides, K. (1992) “An Experimental Investigation of the Suspension Polymerization of Styrene – Methylmethacrylate System
- Athanasiades, I.(1993) “Mathematical Simulation and Control of a Fluidized Bed Reactor for the Production of High Density Polyethylene
- Yiannakitsas, I.(1993) “Mathematical Modelling of Batch Emulsion Polymerization of Vinyl Chloride
- Kammona O. (1993) “Determination of Particle Size Distribution Using a Turbidimetric Technique
- Baltsas, A. (1993) “Mathematical Simulation of Copolymerization Reactions for the Production of Branched Polymers“
- Hambouri, Z. (1993) “Optimization and Optimal Scheduling of Batch Processes
- Kalamatianos, S. (1993) “Chemical Engineering Process Simulations using Neural Networks
- Tsitsifli, S. (1994) “Experimental and Theoretical Investigation of the Stabilization of Monomer Droplets using Polymeric Surfactants
- Mythis, M. (1994) “Dynamic Matrix Control of a Batch Polymerization Reactor
- Stamatas, J. (1994) “A Theoretical Investigation of the Steric Stabilization of Colloidal Dispersion Systems
- Tropios, J. (1994) “Neural Networks Control of Continuous Polymerization Reactors
- Pladis, P. (1994) “Thermodynamic Properties of Ethylene-Polyethylene Mixtures
- Katsis, D. (1994) “Statistical Association Fluid Theory: Verification of the State Equation
- Doufas, A. (1995) “Urea Encapsulation in Polymeric Microparticles for Controlled Release in Aqueous Media
- Kikiras, P. (1995) “Molecular Weight Determination by Viscometry, and Phase Dagrams of Water-Soluble Polymers
- Maggioris, D. – Frantzikinakis, C. (1994) “Lubricant Theory for Viscoelastic Flows”
- Aggelides, C. (1994) “Extrusion of Reinforced Polymers”
- Bountinas, C. – Lezkidou, M. (1995) “Recycling of Polymeric Materials”
- Varnalidou, E. (1995) “Permeability of Aromatic Solvents Through Crosslinked PVA Hydrogel Membranes”
- Houridou, P. (1995) “Synthesis and Characterization of Polyamide Membranes for Controlled Release of Active Ingredients
- Tzanakakis, E. (1995) “Kinetics of Xanthan Gum Production from Whey by Constructed Strains of Xanthomonas Campestris in Batch Fermentations
- Ikonomou, L. (1995) “Microencapsulation of Siconin in Gum
- Tegoulia, V. (1995) “Synthesis of Crosslinked Styrene / Divinyl Benzene Microparticles in an Oil Phase
- Vagelinos, V. (1995) “Mathematical Simulation of the Crosslinking Kinetics of HDPE Using a Numerical Fractionation Technique
- Albanis, J. (1995) “Evaluation of the Light Scattering Techniques for Determining the Particle Size Distribution in Polymeric Latices
- Stavropoulos, J. (1995), “Multivariate Statistical Process Control of LDPE Production Processes Based on Projection to Latent Structures
- Xanthopoulos, T. (1996), “Mathematical Simulation of the Bioadsorption Kinetics
- Tsantekidou, E. (1996), “Characterization of Polymer by Dynamic Mechanical Analysis
- Kehagia, P. – Tzekaki, L. (1996), “Production of Polymeric Particles and their Application in Gel Filtration Chromatography
- Simoglou, A. (1996), “Dynamic Matrix Control of Polymerization Reactors”
- Patziazis, D. (1996), “Optimal Control of Polymerization Reactors
- Giagopoulos, T.- Giannoulakis, H. (1996), “Application of MPC to Polymer Reactors
- Mitraka, M. (1996), “Encapsulation of the Enzyme Amylase in Alginic Acid/Chitosan Microspheres
- Kolozov, M. (1996), “Theoretical Investigation of an Extruded Viscoelastic Fluid Swelling Behaviour”
- Ioannidis, G. (1996), “Monte-Carlo Study on the Thermodynamic Properties of Water
- Zannas, N. (1996), “Applicaiton of Neural Networks in Chemical Engineering”
- Gelatis, I.(1996), “Injection Molding of Reinforced Polymers”
- Minopoulou, E. – Tzika, M. (1996), “Design of a Submerged Extrusion Microencapsulation Device
- Keramopoulos, Α. – Rigopoulos, S. (1997), “Development of a User-Friendly Toolbox Software for Simulation of Polymer Reactors
- Karageorgiou, V. (1998), “Determination of Copolymer Molecular Weight by Gel Permeation Chromatography and Viscometry”
- Proios, P. (1998), “Optimal Fouling Control of Polymerization Reactors with Finite Elements”
- Hatzidoukas, C. – Mantelis, H. (1998), “Kinetics and Thermodynamic Investigation of Polymerization Reactions in Supercritical Fluids”
- Pintzou, Α. (1998), “Theoretical Study of the Drop Size Distribution in Liquid-Liquid Dispersions“
- Papaekonomou I.(1999), “(a) Separation Process Synthesis for the Mixture Taken from Methylacetate Production (b) Synthesis of Methylacetate in a Reactive Distillation Column”
- Zafiri, K. – Kirioglou G. (1999), “Development of Gas Chromatography Techniques for the Analysis of Low-concentrated Monomer Solutions”
- Parouti, S. (1999), “Synthesis of Liposomes by the Extrusion Method”
- Anastasiadis, A. – Chasiotis, A. (1999), “Estimation of Diffusion Coefficient in Polymeric Materials”
- Dimkou, T. (2000), “Combined State Estimation/Process Optimization of Methylmethacrylate Polymerization”
- Boultouka, T. (2000), “Mathematical Modeling of Particle Size Distribution – Application in Vinyl Chloride Polymerization”
- Chronis, A. – , A. (2000), “Theoretical and Experimental Study of Dispersion Polymerization of Methyl Methacrylate in Supercritical Carbon Dioxide”
- Delichristos C. – Mouratides D. (2000), “Phase Equilibria Simulation in Ethylene-Polyethylene Mixtures”
- Koutsodimitropoulos C. (2000), “Installation, Modeling and description of Batch Reactors and Control Systems”
- Kiriakidou Ε. (2000), “Production and Characterization of PHEMA and PHPMA Gel Microparticles produced by Suspension Polymerization”
- Karatrantos Α. (2000), “Mathematical Simulation of the Stripping Process of Polymers from Monomers”
- Xakis Ι. (2001), “Kinetic Study of the Semibatch Emulsion Tripolymerization of Methyl Methacrylate/Butyl Acrylate/Acrylic Acid (ΜΜΑ/BuA/AA)”
- Hatzipartali Κ. (2001), “Design of User Friendly Interface Graphic System for the Mathematic Simulation of the Kinetics of Emulsion Polymerization Reactions”
- Kotsifos G. (2001), “Mixture Phenomena of Ethylene Polymerization Reaction in Autoclave Reactors”
- Kanellopoulos V. (2001), “Mathematical Modeling of Polymer Particle Growth in Heterogeneous Catalytic Olefin Polymerization”
- Saliakas V. (2002), “Graphical User Interface for Chemical Process Simulator with Process-Flow Design Capability”
- Kehagiopoulos P. (2002), “A. Simulation of Chemical Processes using HYSYS. B. Programming and Upgrade of HYSYS to Include Process Mathematical Models: Application to Mathematical Modeling of Continuous MMA/Vac Copolymerization Process”
- Kotrotsiou O. – Pantazatou A. (2002), “Development of characterization techniques for the study of the molecular properties of the tripolymer Methacrylic Methyl ester/ Acrylic Butyl ester/ Acrylic Acid”
- Vittorias I.(2003), “Dynamic Simulation of Stynere Polymerization”
- Koutoufaris Ι. (2003), “Prediction οf Developing Polymeric Particles Internal Morphology During the Gas Olefins Heterogeneous Catalytic Polymerization”
- Meimaroglou D. (2003), “Numerical Solution of Dynamic Optimization Problems on Homo-Polymerization and Co-Polymerization Systems”
- Sgouros A. (2005), “Mathematical Simulation and Process Optimization of Biological Engineering Reactors”
- Anesiadis N.- Touloupidis V. (2005), “Applications of Chemical Engineering using MATLAB”
- Argiropoulou B.G. – Augerinidou G. (2005), “Physical and Chemical Processes Optimization based on Non-linear Calculating Methods”
- Lamprou A. (2006), “Synthesis of Hybrid Polymeric Nanoparticles by Miniemulsion Polymerization”
- Kiparissides D.A. (2006), “Metabolic Control Analysis”
- Georgis D. (2007), “An economical assessment of solar energy based power plant”
- Evaggelidou N. – Bandi A. (2008), “Enzyme Immobilization”
- Apostolidis A., Biliouris C. (2008), “Production of Bioethanol and Biodiesel”
- Marti P., Panagiotou P. (2008), “Synthesis of Biofuels from Renewable Agricultural Sources”
- Kokkinou E. (2010), “Molecular Imprinting Technique for Application in Water Treatment”
- Koutita K. (2010), “Simulation of Angiogenesis and Angiogenesis Inhibition in Cancer”
- Kontonikola Aik. (2010), “Microbial Production of the Biodegradable Poly-(3-hydroxybutyrate) [P(3HB)] via the Fermentation of Cheese Whey by A. Latus”
- Karamanidou Th., Bourganis V. (2010), “Fabrication and Mechanical Characterization of Three-Dimensional, Porous PLGA Scaffolds for Bone and Cartilage Regeneration Applications”
- Douroutlis M. (2011), “Biomimetic Implants and Mechanical Behaviour of the Articular Cartilage”
- Moschidis St. (2011), “Concentrating Solar Thermal Power Technologies for Electricity Generation”
- Pappa A-M. (2012), “Synthesis of Polymeric Nanocarriers for the Mucosal Delivery of Antigens”
- Davris Th. (2012), “Applications of Object Oriented Programming in Chemical Processes”
- Gavriilidou A-F-M. (2012), “Functionalisation and Application of Novel Chromatographic Supports”
- Kyriakou P. (2012), “Development of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for the Oral Administration of Protein”
- Stamatis Ch. (2012), “Production of Biofuels and Chemical Intermediates from Renewable Agro-sources”
- Arsenidis Pr. (2012), “Developement of Non Viral Vectors for the Delivery of Therapeutic Genes”
- Didaskalou Ch. (2013), “Production of Nonocrystalline Cellulose from Renewable Biomass for Biomedical Applications”
- Grigoriadis Th. (2013), “Fermentative Production of Bioethanol and Polyhydroxybutyrate (PHB) from Lingocellulose Derived Sugars”
- Marinos Ch. (2013), “Synthesis and Characterization of PVA Hydrogels for the Repair of Cartilage Defects”
- Gektidis St. (2013), “Population Balances of Cell Cultures in Bioreactors – Steady State Solutions”
- Tsotsou St. (2014), “Extraction of Cellulose Nanocrystals from Lignocellulosic Biomass for Chitosan Reinforcement and Production of Nanocomposite Films for Biodegradable Food Packaging Applications”
- Totti St. (2014), “Extraction of Cellulose Nanocrystals from Lignocellulosic Biomass for Polyvinyl Alcohol (PVA) Reinforcement and Production of Nanocomposite Films for Biomedical Applications”
- Fiotodimitraki Th. (2014), “Computational Study of Ostwald Ripening in Macro- and Nano-scaled Emulsions”
- Tzenos Ch. (2014), “Synthesis and Characterization of Polyacrylamides”
- Masmanidou O. (2015), “Development of Functional Polymeric Nanoparticles Targeting Dendritic Cells”
- Panteli E. (2015), “Dynamic Simulation of Biochemical Conversion Stages of Lignocellulosic Biomass to Ethanol”
- Vasileiadou A. (2016), “Mathematical Modeling of Nanoparticle Diffusion through Biological Membranes”